2-Fluoro-5-(trifluoromethyl)aniline

Basic Information

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CAS Number

535-52-4

Molecular Formula

C7H5F4N

Molecular Weight

179.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

No data available

Boiling Point

190°C

Refractive Index

n20/D 1.461(lit.)

SMILES

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C1=CC(=C(C=C1C(F)(F)F)N)F

InChI

InChI=1S/C7H5F4N/c8-5-2-1-4(3-6(5)12)7(9,10)11/h1-3H,12H2

InChIKey

DRKWGMXFFCPZLW-UHFFFAOYSA-N

LogP

2.4267000000000003

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

156

Safety Information

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GHS Hazard Pictograms

H302

H312

H315

H319

H332

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

DTXSID80201710
NSC 10327
EN300-67467
2-fluoro-5-trifluoromethyl aniline
2-fluoro-5-(trifluoromethyl) aniline
A7788
2-Fluoro-5-(trifluoromethyl)aniline, 97%
3-Amino-4-fluorobenzotrifluoride
2-fluoro-5-trifloromethyl aniline
2-Fluoro-5-(trifluoromethyl)aniline
CS-W017290
535-52-4
Benzenamine, 2-fluoro-5-(trifluoromethyl)-
3-amino-4-fluoro benzotrifluoride
Z275189668
AKOS003284066
a,a,a,6-Tetrafluoro-m-toluidine
2-Fluoro-5-(trifluoromethyl)aniline #
2-fluoro-5-trifluoromethylanilin
FT-0614972
PS-8550
AM20060249
alpha,alpha,alpha,6-Tetrafluoro-m-toluidine
NSC-10327
.alpha.,.alpha.,.alpha.,6-Tetrafluoro-m-toluidine
AC-26227
NSC10327
2-Fluoro-5-trifluoromethylaniline
2-fluoro-5-(trifluoromethyl)benzenamine
MFCD00007653
SCHEMBL309479

MDL Number

MFCD00007653

Customs Code

2921420090

FAQ

What regulatory guidelines apply to 2-Fluoro-5-(trifluoromethyl)aniline (CAS: 535-52-4)?

2-Fluoro-5-(trifluoromethyl)aniline (CAS: 535-52-4) is regulated under the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) as a hazardous substance due to its flammability and potential for skin and eye irritation. It falls under the REACH regulations in the European Union, requiring manufacturers and importers to register and manage the risks associated with the substance. In the United States, the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA) have specific requirements for handling, storage, and disposal. Proper documentation and safety data sheets (SDS) must be maintained and available for review.

Are there alternatives to 2-Fluoro-5-(trifluoromethyl)aniline (CAS: 535-52-4) in synthesis?

There are alternative reagents and compounds that can be used in synthesis as substitutes for 2-Fluoro-5-(trifluoromethyl)aniline (CAS: 535-52-4). For example, 4-Fluoro-2-(trifluoromethyl)aniline and 3-Fluoro-6-(trifluoromethyl)aniline are similar compounds that can serve as alternatives in certain chemical processes. These alternatives may vary in reactivity and may require different reaction conditions, but they offer a viable path to achieve similar outcomes in synthesis.

What is the market or research trend for 2-Fluoro-5-(trifluoromethyl)aniline (CAS: 535-52-4)?

The market for 2-Fluoro-5-(trifluoromethyl)aniline (CAS: 535-52-4) is driven by its use in the pharmaceutical and chemical industries. Research trends indicate a steady demand for this compound, particularly for its role as an intermediate in drug synthesis and as a reagent in organic chemistry. Emerging trends include its use in materials science for developing advanced polymers and electronics. Market dynamics suggest a focus on sustainable and green chemistry approaches, which may influence the development of more environmentally friendly alternatives in the future.

How should waste containing 2-Fluoro-5-(trifluoromethyl)aniline (CAS: 535-52-4) be handled?

Waste containing 2-Fluoro-5-(trifluoromethyl)aniline (CAS: 535-52-4) should be handled according to local, state, and federal regulations. Waste should be collected in appropriate containers and labeled with the correct hazard symbols and waste codes. It should be stored separately and securely to prevent contamination of the environment. Incineration or professional waste disposal methods are recommended to ensure proper disposal. Environmental protection precautions include proper ventilation and the use of personal protective equipment (PPE) to minimize exposure. Consulting with a hazardous waste disposal expert can provide guidance on specific disposal methods and compliance with regulatory requirements.