Rapamycin | CAS No. 53123-88-9

Rapamycin

Basic Information

CAS Number

53123-88-9

Molecular Formula

C51H79NO13

Molecular Weight

914.19 g/mol

AD

Basic Physical Properties

Melting Point

183-194°C

Boiling Point

973°C at 760 mmHg

Density

1.0352 (rough estimate)

Water Solubility

Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.

Flash Point

2℃(35.6℉)(lit.)

Solubility

ethanol: soluble2MM

Refractive Index

1.5280 (estimate)

Specific Rotation

-58.2° (MeOH)

CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C(\C)/[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC)CC[C@H]1O

InChI

InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

InChIKey

QFJCIRLUMZQUOT-HPLJOQBZSA-N

LogP

6.180600000000008

Topological Polar Surface Area

195.42999999999998 Ų

Hydrogen Bond Donor/Acceptor

3 / 14

Complexity

1760

Safety Information

View Safety Information

Hazard Statement

H371 May cause damage to organs
Specific target organ toxicity, single exposure
H373 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Toxicity

LD50 in mice (mg/kg): 600 i.p.; >2,500 orally (Vézina)

Synonyms & References

English

  • rapamycin from streptomyces*hygroscopicus
  • 23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE
  • AY 22989
  • NSC-226080
  • RAPA
  • RAPAMUNE
  • RAPAMYCIN
  • RAPAMYCIN, STREPTOMYCES HYGROSCOPICUS
  • RPM
  • SIROLIMUS
  • antibioticay22989
  • sila9268a
  • WYETH RAPAMYCIN, 1GM
  • RAPAMYCIN 1GM
  • RAPAMYCIN, STANDARD WITH MS, NMR RESULT
  • Rapamicin
  • Rapamicin(sirolimus )
  • Rapamycin (AY 22989, Sirolimus, RAPA,NSC 226080, Rapamune®)
  • Rapamycin (Sirolimus)
  • Sirolimus solution
  • Siroliums
  • &nbsp
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine,AY 22989,Sirolimus
  • Rapamycin from Streptomyces hygroscopicus
  • Resorcinol
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine
  • (-)-Rapamycin
  • Rapammune
  • sirolimusum
  • Antibiotic AY 22989
  • SILA 9268A

MDL Number

MFCD00867594

Customs Code

2942000000

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