1-Ethylpiperazine

Basic Information

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CAS Number

5308-25-8

Molecular Formula

C6H14N2

Molecular Weight

114.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

-60 ºC

Boiling Point

157 °C

Solubility

soluble

Refractive Index

n20/D 1.469(lit.)

SMILES

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CCN1CCNCC1

InChI

InChI=1S/C6H14N2/c1-2-8-5-3-7-4-6-8/h7H,2-6H2,1H3

InChIKey

WGCYRFWNGRMRJA-UHFFFAOYSA-N

LogP

-0.08850000000000002

Topological Polar Surface Area

15.27 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

57.5

Safety Information

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GHS Hazard Pictograms

H226

H315

H319

H335

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Sensitiveness

Air Sensitive

Synonyms & References

English

1-Ethylpiperazine
NSC60707
A7732
TS-01586
1-Ethyl-2,5-dihydropiperazine
SB11216
1-Ethylpiperazine, 98%
1-ethylpiperazin
NSC-60707
EINECS 226-166-6
Q27265616
Piperazine, 1-ethyl-
1-ethylpiperizine
1-ethyl-piperazine
ethypiperazine
N-ethylpiperizine
N-Ethyl piperazine(NEP)
AKOS000119093
1-ethlypiperazine
FT-0652510
W-105771
DTXSID8073346
EC 226-166-6
N-ETHYLPIPERAZINE [USP-RS]
6W2BW0V73G
P17082
MFCD00059912
Piperazine, 1-ethyl-; 1-Ethylpiperazine; N-Ethylpiperazine; NSC 60707
N-Ethylpiperazine, United States Pharmacopeia (USP) Reference Standard
1-ethyl piperazine
UNII-6W2BW0V73G

MDL Number

MFCD00059912

Customs Code

2933599090

FAQ

What is 1-Ethylpiperazine (CAS: 5308-25-8)?

1-Ethylpiperazine (CAS: 5308-25-8) is a piperazine derivative with the chemical formula C7H14N2. It is a colorless, hygroscopic liquid with a faint amine odor, commonly used as an intermediate in organic synthesis. Its structure features a six-membered ring with two nitrogen atoms and an ethyl group attached to one of the ring positions, contributing to its chemical reactivity and utility in various applications.

What are the main uses of 1-Ethylpiperazine (CAS: 5308-25-8)?

1-Ethylpiperazine (CAS: 5308-25-8) is primarily used in pharmaceutical research as a building block for drug development, including antihistamines and antipsychotics. It also serves as a solvent in industrial processes and a reagent in chemical synthesis. Additionally, it is employed in polymer science and as a component in certain analytical procedures, leveraging its structural versatility and chemical properties.

Is 1-Ethylpiperazine (CAS: 5308-25-8) safe?

1-Ethylpiperazine (CAS: 5308-25-8) is generally considered low in toxicity but requires caution during handling. It may cause skin or eye irritation, so protective gloves, goggles, and proper ventilation are recommended. Safety standards advise following OSHA guidelines and using appropriate personal protective equipment (PPE) to minimize exposure. Always refer to the safety data sheet (SDS) for detailed information.

How should 1-Ethylpiperazine (CAS: 5308-25-8) be stored?

1-Ethylpiperazine (CAS: 5308-25-8) should be stored in a sealed, cool (below 25°C), and dry place, away from light. It is hygroscopic, so airtight containers are essential to prevent moisture absorption. Avoid storage near incompatible substances, and maintain stability by keeping it in a well-ventilated area. Refrigeration may be necessary for long-term preservation.