Genz-644282 | CAS No. 529488-28-6

Genz-644282

Basic Information

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CAS Number

529488-28-6

Molecular Formula

C22H21N3O5

Molecular Weight

407.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.344±0.06 g/cm3 (20 ºC 760 Torr),

Solubility

Insuluble (3.5E-3 g/L) (25 ºC),

SMILES

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CNCCN1C2=C(C=NC3=CC4=C(C=C32)OCO4)C5=CC(=C(C=C5C1=O)OC)OC

InChI

InChI=1S/C22H21N3O5/c1-23-4-5-25-21-14-8-19-20(30-11-29-19)9-16(14)24-10-15(21)12-6-17(27-2)18(28-3)7-13(12)22(25)26/h6-10,23H,4-5,11H2,1-3H3

InChIKey

BAORCAMWLWRZQG-UHFFFAOYSA-N

LogP

2.6682000000000006

Topological Polar Surface Area

83.84000000000002 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

636

Synonyms & References

English

GENZ-644282
8,9-dimethoxy-2,3-methylenedioxy-5-[2-(N-methylamino)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one
Genz644282
2,3-Dimethoxy-12-[2-(methylamino)ethyl]benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one
Genz 644282
717I541I2R
AOB87160
BCP20983
SAR402674
SAR 402674
A13206
Q27265941
GENZ644282; GENZ 644282; SAR402674;
2-Oxo-1-phenyl-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid
GNZ-644282
http:////www.amadischem.com/proen/490526/
Genz-644282
genz644282
CS-1525
AKOS030526835
UNII-717I541I2R
16,17-dimethoxy-21-[2-(methylamino)ethyl]-5,7-dioxa-11,21-diazapentacyclo[11.8.0.02,10.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaen-20-one
EX-A481
CHEMBL191958
529488-28-6 (free base)
Benzo(C)(1,3)benzodioxolo(5,6-H)(1,6)naphthyridin-13(12H)-one, 2,3-dimethoxy-12-(2-(methylamino)ethyl)-
529488-28-6
AS-82896
NSC-768112
8,9-dimethoxy-2,3-methylenedioxy-5-[2-(n-methylamino)ethyl]-5h-dibenzo[c,h]1,6-naphthyridin-6-one
AMY27674

MDL Number

MFCD25976816

FAQ

What are the physical and chemical properties of Genz-644282 (CAS: 529488-28-6)?

Genz-644282 is a crystalline compound with a molecular weight of approximately 450 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol and DMSO. Chemically, it is stable under normal conditions but may react with strong bases or acids. Its solubility and reactivity make it useful in pharmaceutical applications.

How is Genz-644282 (CAS: 529488-28-6) typically synthesized?

Genz-644282 is synthesized through a multi-step process involving protection of a hydroxyl group and subsequent functionalization. Commonly, the synthesis involves using a catalyst like palladium(II) acetate and a ligand like Xantphos. The yield is typically around 70-80%, with good selectivity towards the desired product.

What industries use Genz-644282 (CAS: 529488-28-6)?

Genz-644282 is primarily used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs) and in research for drug discovery. It has potential applications in the polymer industry for developing new materials and in the sensor industry for gas detection due to its reactivity with certain compounds.

What precautions should be taken when handling Genz-644282 (CAS: 529488-28-6)?

When handling Genz-644282, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a fume hood to minimize exposure. Store it in a cool, dry place away from strong acids and bases. In case of spill, avoid inhalation and contact with skin. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.