2-Amino-5-bromonicotinic acid

Basic Information

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CAS Number

52833-94-0

Molecular Formula

C6H5BrN2O2

Molecular Weight

217.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

256-259°C

Boiling Point

350.4℃ at 760 mmHg

Density

1.909

Flash Point

165.7℃

Refractive Index

1.5150 (estimate)

SMILES

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C1=C(C=NC(=C1C(=O)O)N)Br

InChI

InChI=1S/C6H5BrN2O2/c7-3-1-4(6(10)11)5(8)9-2-3/h1-2H,(H2,8,9)(H,10,11)

InChIKey

IEPDTLRHISNBLB-UHFFFAOYSA-N

LogP

1.1245

Topological Polar Surface Area

76.21 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

165

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

SCHEMBL836163
2-amino5-bromonicotinic acid
2-amino-5-bromo-3-carboxypyridine
SY002955
IEPDTLRHISNBLB-UHFFFAOYSA-N
EN300-113866
528333-94-0
2-Amino-5-bromonicotonic acid
2-amino-5-bromopyridine-3-carboxylic acid
SB10157
DTXSID60353241
2-amino-5-bromo-3-pyridine carboxylic acid
2-amino-5-bromonicotinicacid
11W-0705
2-amino-5-bromonicotinic acid
3-Pyridinecarboxylic acid, 2-amino-5-bromo-
A7712
AKOS005064141
3-Pyridinecarboxylic acid, 2-amino-5-bromo
J-507917
MFCD01860227
5-bromo-2-aminonicotinic acid
FT-0600890
5-Bromo-2-Amino Nicotinic Acid
AJ-333/25022118
AM20061284
2-AMINO-5-BROMO-3-PYRIDINECARBOXYLIC ACID
Z905189356
CS-W002834
2-AMINO-5-BROMO-NICOTINIC ACID
AC-2801

MDL Number

MFCD01860227

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Amino-5-bromonicotinic acid (CAS: 52833-94-0)?

2-Amino-5-bromonicotinic acid is a white to off-white crystalline solid with a molecular weight of approximately 246.04 g/mol. It is slightly soluble in water and soluble in organic solvents. This compound is reactive and can undergo nucleophilic substitution reactions, particularly with amines and thiols.

How is 2-Amino-5-bromonicotinic acid (CAS: 52833-94-0) typically synthesized?

2-Amino-5-bromonicotinic acid can be synthesized by bromination of nicotinic acid followed by an amino substitution reaction. Commonly, nicotinic acid is brominated using N-bromosuccinimide (NBS) or bromine in the presence of a base like potassium carbonate. The amino group is introduced via an amine nucleophile in the presence of a suitable catalyst such as sodium hydride.

What industries use 2-Amino-5-bromonicotinic acid (CAS: 52833-94-0)?

2-Amino-5-bromonicotinic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry as a precursor for the preparation of advanced polymers with specific properties. Additionally, it has applications in the development of sensors and other materials used in the semiconductor industry.

What precautions should be taken when handling 2-Amino-5-bromonicotinic acid (CAS: 52833-94-0)?

When handling 2-Amino-5-bromonicotinic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation of fumes. Spills should be handled carefully, using absorbent materials or a spill kit, and the area should be cleaned according to safety data sheet (SDS) guidelines. Ensure that all materials are properly disposed of in accordance with local regulations.