1-Methyl-5-oxo-L-proline

Basic Information

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CAS Number

52574-06-8

Molecular Formula

C6H9NO3

Molecular Weight

143.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CN1C(CCC1=O)C(=O)O

InChI

InChI=1S/C6H9NO3/c1-7-4(6(9)10)2-3-5(7)8/h4H,2-3H2,1H3,(H,9,10)/t4-/m0/s1

InChIKey

SHLYZEAOVWVTSW-BYPYZUCNSA-N

LogP

-0.3082000000000003

Topological Polar Surface Area

57.61 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

178

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SCHEMBL647325
1-METHYL-5-OXO-PROLINE
AKOS006380138
52574-06-8
A870954
(S)-1-Methyl-5-oxopyrrolidine-2-carboxylicacid
1-Methyl-5-oxo-L-Proline
CCA57406
(S)-1-Methyl-5-oxopyrrolidine-2-carboxylic acid
N-methyl-5-oxoproline
MFCD19228297
SHLYZEAOVWVTSW-BYPYZUCNSA-N
1-methyl-5-oxoproline
N-methylpyroglutamic acid
AMY16244
NS00063416
(2S)-1-methyl-5-oxopyrrolidine-2-carboxylic acid
EN300-130825
DTXSID00595365
CS-0030793
DS-9685
1-methyl-5-oxo-L-Proline
L-Proline, 1-methyl-5-oxo-
1-Methylpyroglutamic acid
NE62550
ST24035755

MDL Number

MFCD19228297

FAQ

What are the physical and chemical properties of 1-Methyl-5-oxo-L-proline (CAS: 52574-06-8)?

The physical properties of 1-Methyl-5-oxo-L-proline include a melting point of 128-129°C. It has a molecular weight of 150.22 g/mol and is slightly soluble in water. Chemically, it is relatively stable but can react with strong nucleophiles. It is a solid with a crystalline form.

How is 1-Methyl-5-oxo-L-proline (CAS: 52574-06-8) typically synthesized?

1-Methyl-5-oxo-L-proline can be synthesized through the condensation of L-proline and methylamine. The reaction is catalyzed by a transition metal, such as palladium, and proceeds with high selectivity, yielding a high purity product.

What industries use 1-Methyl-5-oxo-L-proline (CAS: 52574-06-8)?

1-Methyl-5-oxo-L-proline is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in polymer science for the creation of specific copolymers and in the development of sensors due to its unique chemical properties.

What precautions should be taken when handling 1-Methyl-5-oxo-L-proline (CAS: 52574-06-8)?

When handling 1-Methyl-5-oxo-L-proline, ensure the use of personal protective equipment (PPE) such as gloves and goggles. Work under a fume hood to avoid inhalation. In case of a spill, immediately clean up with appropriate absorbents and follow the Material Safety Data Sheet (MSDS) for disposal.