Teriparatide | CAS No. 52232-67-4

Teriparatide

Basic Information

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CAS Number

52232-67-4

Molecular Formula

C181H291N55O51S2

Molecular Weight

4118 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCC(C)C(C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC2=CNC=N2)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC5=CNC=N5)C(=O)NC(CC(=O)N)C(=O)NC(CC6=CC=CC=C6)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CO)N

InChI

InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)

InChIKey

OGBMKVWORPGQRR-UHFFFAOYSA-N

LogP

-15.240260000000273

Topological Polar Surface Area

1752.6499999999987 Å²

Hydrogen Bond Donor/Acceptor

71 / 106

Complexity

9740

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H351 Suspected of causing cancer
Carcinogenicity

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

Teriparatide acetate
52232-67-4
Teriparatide(Forteo)
AKOS034831562
Human parathyroid hormone-(1-34);hPTH (1-34)
H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
(4S)-4-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-3-car
EX-A7393
TERIPARATIDE
ZDA29494
Teriparatide acetate hydrate
[CYS5,28] PARATHYROID HORMONE (1-34), HUMAN[CYS5,28] PTH (1-34), HUMANH-SER-VAL-SER-GLU-ILE-GLN-LEU-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-OHPARATHYROID HORMONE (1-34), HUMANPARATHYROID HORMONE (HUMAN, 1-34)PARATHYROID HORMONE HUMAN: FRAGMENT 1-34PTH (1-34) (HUMAN)PTH (HUMAN, 1-34)SER-VAL-SER-GLU-ILE-GLN-LEU-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-T
Parathyroid Hormone Fragment (1-34)
Parathyroid Hormone
Parathyroid hormone (1-34) (human)
pTH (1-34) (human)
Teriparatide
hPTH (1-34)
Human parathyroid hormone-(1-34)
PTH 1-34

MDL Number

MFCD00149013

FAQ

What is Teriparatide (CAS: 52232-67-4)?

Teriparatide is a synthetic analog of parathyroid hormone (PTH), specifically designed to mimic the action of the naturally occurring hormone. Its chemical formula is C18H34N2O6S2. It is a peptide with a molecular weight of approximately 409.58 g/mol and is known for its ability to stimulate bone formation. Teriparatide is primarily used in the treatment of osteoporosis and is available as a prescription medication.

What are the main uses of Teriparatide (CAS: 52232-67-4)?

Teriparatide is mainly used for the treatment of osteoporosis, particularly in postmenopausal women and men with a high risk of fractures. It is also used in patients with osteogenesis imperfecta. In addition to its pharmaceutical applications, Teriparatide may be used in research settings for studying bone metabolism and as a tool for drug development related to bone health. Its use in industry is limited due to its specific biological function.

Is Teriparatide (CAS: 52232-67-4) safe?

Teriparatide is generally considered safe when used as directed under medical supervision. However, it may cause side effects such as hypocalcemia, hypercalcemia, and changes in bone metabolism. Proper handling and administration are essential to ensure safety. It is important to follow safety guidelines and consult healthcare professionals for appropriate use and monitoring.

How should Teriparatide (CAS: 52232-67-4) be stored?

Teriparatide should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 2°C to 8°C (refrigerated) and should not be exposed to moisture or humidity. The medication should be stored in its original container to maintain stability and prevent degradation. Always check the manufacturer's instructions for specific storage requirements.