4-Chloro-1,3-thiazol-2-amine

Basic Information

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CAS Number

52107-46-7

Molecular Formula

C3H3ClN2S

Molecular Weight

134.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

Melting Point

181-182 ºC

Boiling Point

260.5±13.0 ºC (760 Torr),

Density

1.558±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

111.3±19.8 ºC,

SMILES

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Nc1nc(Cl)cs1

InChI

InChI=1S/C3H3ClN2S/c4-2-1-7-3(5)6-2/h1H,(H2,5,6)

InChIKey

XGWAKKLWGVLLDB-UHFFFAOYSA-N

LogP

1.3787

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Synonyms & References

English

4-Chlorothiazol-2-amine
2-AMINO-4-CHLOROTHIAZOLE
4-chloro-1,3-thiazol-2-amine
4-Chloro-thiazol-2-ylamine
4-chloro-2-aminothiazol
4-Chlor-thiazol-2-ylamin
QC-6332
4-Chloro-2-aminothiazole
4-chlorothiazol-2-amine

MDL Number

MFCD09999189

FAQ

What are the physical and chemical properties of 4-Chloro-1,3-thiazol-2-amine (CAS: 52107-46-7)?

4-Chloro-1,3-thiazol-2-amine is a solid at room temperature, with a molecular weight of approximately 147.03 g/mol. It is slightly soluble in water and has good solubility in organic solvents such as ethanol and DMSO. Chemically, it is relatively stable but can react with strong bases to form thiazoles. It is also known for its ability to participate in nucleophilic substitution reactions.

How is 4-Chloro-1,3-thiazol-2-amine (CAS: 52107-46-7) typically synthesized?

4-Chloro-1,3-thiazol-2-amine is typically synthesized through a multistep process involving the reaction of 2-aminothiazole with hydrochloric acid. This reaction is carried out under reflux conditions, yielding a high yield of the target compound. The reaction is selective and can be optimized using appropriate catalysts to improve efficiency.

What industries use 4-Chloro-1,3-thiazol-2-amine (CAS: 52107-46-7)?

4-Chloro-1,3-thiazol-2-amine is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for the modification of polymer properties, and in the sensor industry for developing chemical sensors. Additionally, it has applications in the semiconductor industry due to its unique chemical properties.

What precautions should be taken when handling 4-Chloro-1,3-thiazol-2-amine (CAS: 52107-46-7)?

When handling 4-Chloro-1,3-thiazol-2-amine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be handled with caution using appropriate absorbents, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed safety instructions.