Benzhexol HCl (Trihexyphenidyl HCl)

Basic Information

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CAS Number

52-49-3

Molecular Formula

C20H32ClNO

Molecular Weight

337.94 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

258.5oC

Boiling Point

447.9°C at 760mmHg

Flash Point

211°C

Solubility

H2O: soluble

Refractive Index

1.5790 (estimate)

SMILES

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Cl.OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3

InChI

InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H

InChIKey

QDWJJTJNXAKQKD-UHFFFAOYSA-N

LogP

4.752300000000004

Topological Polar Surface Area

23.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

314

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1(b) Class 6.1(b)

Synonyms & References

English

benzhexol hydrochloride
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride
alpha-Cyclohexyl-alpha-phenyl-1-piperidinepropanol,HCl
Artane
Trihexane
Trihexy
Trihexyphenidyl hydrochloride
1-Cyclohexyl-1-Phenyl-3-Piperidine Propanol Hydrochloride
Trihexyphenidyl HCL
1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride
D,L-Trihexyphenidyl Hydrochloride
D,L-Trihexyphenidyl,
Trihexyphenidyl (hydrochloride)
Broflex
cyclodol
pacitane
paralest
peragit
pipanol
Sedrina
tremin
trihexylphenidyl HCl
(±)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride
α-Cyclohexyl-α-phenyl-1-piperidinepropanol Hydrochloride
1-Cyclohexyl-1-phenyl-3-(1-piperidyl)-1-propanol Hydrochloride
1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
hydrochloride (1:1)

MDL Number

MFCD00058212

Customs Code

2933990090

FAQ

What is Benzhexol HCl (CAS: 52-49-3)?

Benzhexol HCl, also known as trihexyphenidyl HCl, is a muscarinic antagonist used in the treatment of Parkinson's disease and other conditions involving muscle stiffness and tremors. Its chemical formula is C21H25NO.HCl. This compound has anticholinergic properties and is widely used in pharmaceuticals.

What are the main uses of Benzhexol HCl (CAS: 52-49-3)?

Benzhexol HCl is primarily used in the treatment of Parkinson's disease to alleviate symptoms such as tremors, muscle stiffness, and bradykinesia. It is also used to manage side effects of antipsychotic medications and to treat symptoms of overactive bladder.

Is Benzhexol HCl (CAS: 52-49-3) safe?

Benzhexol HCl is generally safe when used as directed by a healthcare provider. However, it is important to follow all precautions and safety guidelines. Toxicity can occur with high doses, and users should avoid contact with eyes, skin, and inhalation. Proper storage and handling are crucial to ensure safety.

How should Benzhexol HCl (CAS: 52-49-3) be stored?

Benzhexol HCl should be stored at room temperature, between 15-30°C (59-86°F), away from direct sunlight and moisture. It should be kept in a tightly sealed container to prevent degradation. Avoid exposure to heat and humidity, and store it out of reach of children and pets.