8-Ethyl-5-oxo-2-(1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid

Basic Information

View in Editor

CAS Number

51940-44-4

Molecular Formula

C14H17N5O3

Molecular Weight

303.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

251-255℃

Boiling Point

534.9°C at 760 mmHg

Water Solubility

Soluble in 1N sodium hydroxide or in DMSO. Insoluble in water

Flash Point

>110°(230°F)

Solubility

1 M NaOH: soluble50mg/mL

Refractive Index

1.7000 (estimate)

SMILES

View in Editor

CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCNCC3)C(=O)O

InChI

InChI=1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)

InChIKey

JOHZPMXAZQZXHR-UHFFFAOYSA-N

LogP

-0.08080000000000004

Topological Polar Surface Area

100.35000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 8

Complexity

489

Safety Information

View Safety Information

GHS Hazard Pictograms

H317

H334

Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

Sensitiveness

Light Sensitive

Toxicity

LD50 in mice (mg/kg): 4000 orally; 1000 i.p., 50 i.v. (Ficicchia)

Synonyms & References

English

SPBio_001229
NCGC00016866-02
Deblaston
SPECTRUM1502024
Pipurin
D08379
Pipemidic acid [INN:BAN:DCF]
IDI1_000651
NCGC00023999-03
Tox21_110655
NCGC00178314-01
A828860
Acide pipemidique
Spectrum_001387
Filtrax
SR-01000000245-2
Pipemidic acid, Antibiotic for Culture Media Use Only
F15437
Uromidin
Pipemidic
CS-4838
CHEMBL30116
EINECS 257-530-2
Prestwick3_000897
Nuril (TN)
8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidine-6-carboxylicacidtrihydrate
Q754986
Pipemidate
SMP1_000242
UNII-LT12J5HVR8
Spectrum5_001214

MDL Number

MFCD03074065

FAQ

What is 8-Ethyl-5-oxo-2-(1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid (CAS: 51940-44-4)?

8-Ethyl-5-oxo-2-(1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid, also known as ABT-701, is a chemical compound with a complex structure. It is a derivative of a pyrido-pyrimidine class of compounds, which are known for their biological activities. This compound is often used in research for its potential pharmacological effects.

What are the main uses of 8-Ethyl-5-oxo-2-(1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid (CAS: 51940-44-4)?

8-Ethyl-5-oxo-2-(1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid is primarily used in the research and development of new drug candidates, particularly in the field of oncology due to its potential antitumor properties. It is also being studied for other therapeutic applications.

Is 8-Ethyl-5-oxo-2-(1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid (CAS: 51940-44-4) safe?

The safety of 8-Ethyl-5-oxo-2-(1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid depends on the context of use. It is essential to follow all safety guidelines and handle it with appropriate personal protective equipment (PPE) such as gloves and goggles. It is recommended to consult the Material Safety Data Sheet (MSDS) for detailed safety information and precautions.

How should 8-Ethyl-5-oxo-2-(1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid (CAS: 51940-44-4) be stored?

This compound should be stored in a cool, dry place away from direct sunlight and heat sources. It is best to keep it in a tightly sealed container to prevent degradation. The storage temperature should be maintained between 15-25°C. Avoid contact with incompatible materials and ensure the storage area is well-ventilated.