Cefatrizine | CAS No. 51627-14-6

Cefatrizine

Basic Information

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CAS Number

51627-14-6

Molecular Formula

C18H18N6O5S2

Molecular Weight

462.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

948.1°Cat760mmHg

Flash Point

527.2°C

Refractive Index

1.7000 (estimate)

SMILES

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C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)CSC4=NNN=C4

InChI

InChI=1S/C18H18N6O5S2/c19-12(8-1-3-10(25)4-2-8)15(26)21-13-16(27)24-14(18(28)29)9(7-31-17(13)24)6-30-11-5-20-23-22-11/h1-5,12-13,17,25H,6-7,19H2,(H,21,26)(H,28,29)(H,20,22,23)/t12-,13-,17-/m1/s1

InChIKey

UOCJDOLVGGIYIQ-PBFPGSCMSA-N

LogP

0.04099999999999954

Topological Polar Surface Area

174.52999999999997 Å²

Hydrogen Bond Donor/Acceptor

6 / 11

Complexity

775

Safety Information

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Toxicity

LD50 in male, female mice, male, female rats (mg/kg): 6880, 6410, 4325, 4325 i.p. (Matsuzaki)

Synonyms & References

English

CEFATRIZINE [MI]
Antibiotic BL-S 640
(6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-8-oxo-3-[(2H-triazol-4-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
S 640P
t-amyl
Q3009981
DTXSID7022752
CHEBI:131730
BL-S640
NCGC00185755-01
Cefatrizino [INN-Spanish]
CEFATRIZINE
GTPL12204
DB13266
D02406
Tox21_113376
Trizina
Cefatrizine [USAN:INN:BAN]
CEFATRIZINE PROPYLENE GLYCOLATE [JAN]
(6R,7R)-3-(acetoxymethyl)-7-(2-((E)-N,N'-diisopropylcarbamimidoylthio)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CEFATRIZINE [USAN]
(6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CS-0079891
CEFATRIZINE PROPYLENE GLYCOL
cefatrizina
(6R,7R)-3-(((1H-1,2,3-Triazol-5-yl)thio)methyl)-7-((R)-2-amino-2-(4-hydroxyphenyl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SKF 60771
CEFATRIZINE [WHO-DD]
CAS-51627-14-6
A828691
Bricef

MDL Number

MFCD01940014

FAQ

What regulatory guidelines apply to Cefatrizine (CAS: 51627-14-6)?

Cefatrizine (CAS: 51627-14-6) is subject to various regulatory guidelines including the Globally Harmonized System (GHS), REACH regulations, and FDA/EPA requirements. It must comply with GHS classifications for hazardous properties, REACH for registration, evaluation, and authorization of chemicals, and FDA/EPA for safety and environmental handling. Ensure all handling and disposal practices adhere to local and international regulations.

Are there alternatives to Cefatrizine (CAS: 51627-14-6) in synthesis?

Several alternatives to Cefatrizine include other cephalosporin antibiotics such as cefdinir and cefuroxime. Isomeric forms and analogs like cefixime can also be considered. Common alternative reagents in synthesis include β-lactam rings from which Cefatrizine is derived. Evaluate these options based on specific application needs and regulatory compliance.

What is the market or research trend for Cefatrizine (CAS: 51627-14-6)?

Cefatrizine (CAS: 51627-14-6) shows ongoing interest in the pharmaceutical industry due to its broad-spectrum antibacterial properties. Research trends include cost-effectiveness studies and efficacy in resistant bacterial infections. Market demand is driven by emerging markets and increasing patient needs. However, there is a growing emphasis on environmental sustainability and minimizing waste in research and production processes.

How should waste containing Cefatrizine (CAS: 51627-14-6) be handled?

Waste containing Cefatrizine (CAS: 51627-14-6) should be collected, stored, and disposed of in accordance with local and international regulations. Collect waste in appropriate containers and label them with the chemical name and CAS number. Incineration or professional waste disposal services should be utilized. Implement proper environmental protection measures, such as containment and neutralization, to prevent contamination. Always consult and follow the latest regulatory guidelines for disposal methods.