(R)-2-Flurbiprofen

Basic Information

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CAS Number

51543-40-9

Molecular Formula

C15H13FO2

Molecular Weight

244.27 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

Melting Point

110-113 °C

Boiling Point

376.2±30.0 °C at 760 mmHg

Density

1.2±0.1 g/cm3

Flash Point

181.3±24.6 °C

Refractive Index

1.34

Vapor Pressure

0.0±0.9 mmHg at 25°C

SMILES

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OC(=O)[C@@H](c1ccc(c(c1)F)c1ccccc1)C

InChI

1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1

InChIKey

SYTBZMRGLBWNTM-SNVBAGLBSA-N

LogP

3.6808000000000023

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

286

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

(2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid
Flurbiprofen
(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid
[1,1'-biphenyl]-4-acetic acid, 2-fluoro-alpha-methyl-, (alphaR)-
(R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid
(R)-(?)-2-Fluoro-α-methyl-4-biphenylacetic acid
(R)-2-Flurbiprofen
(R)-Flurbiprofen
Flurizan
R-(-)-Flurbiprofen
(2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid
E7869
E-7869
MPC7869
MPC-7869
tarenflurbil
UNII-501W00OOWA
(R)-2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic acid
Tarenflurbil
(R)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoic acid

MDL Number

MFCD00869714

Customs Code

2916399090

FAQ

What regulatory guidelines apply to (R)-2-Flurbiprofen (CAS: 51543-40-9)?

The (R)-2-Flurbiprofen (CAS: 51543-40-9) is subject to various regulatory guidelines including GHS classification, REACH regulations, and FDA/EPA requirements. It is classified as a non-steroidal anti-inflammatory drug (NSAID) and must comply with safety and labeling standards for pharmaceuticals. Companies must ensure compliance with these guidelines during manufacturing, storage, and distribution to meet international safety and regulatory requirements.

Are there alternatives to (R)-2-Flurbiprofen (CAS: 51543-40-9) in synthesis?

Yes, there are alternatives to (R)-2-Flurbiprofen (CAS: 51543-40-9) in synthesis, such as other NSAIDs like ibuprofen or naproxen. Isomers and analogs, such as (S)-2-flurbiprofen, can also be used. Common alternative reagents include different chiral auxiliaries or asymmetric synthesis methods to produce enantiopure compounds. These alternatives can provide similar or improved pharmacological properties depending on the specific application.

What is the market or research trend for (R)-2-Flurbiprofen (CAS: 51543-40-9)?

The market for (R)-2-Flurbiprofen (CAS: 51543-40-9) is stable due to its established therapeutic use as a non-steroidal anti-inflammatory drug. Research trends focus on understanding its mechanism of action, potential for treating inflammatory conditions, and minimizing side effects. Recent studies also explore the potential of (R)-2-Flurbiprofen in combination therapies and its role in chronic pain management. The trend shows increasing demand for effective and safe NSAIDs in the pharmaceutical industry.

How should waste containing (R)-2-Flurbiprofen (CAS: 51543-40-9) be handled?

Waste containing (R)-2-Flurbiprofen (CAS: 51543-40-9) should be handled according to appropriate disposal regulations. Waste liquid should be collected in suitable containers and neutralized to a pH of 7-8 before disposal. Incineration or professional waste disposal services are recommended to ensure complete destruction of the compound. Environmental protection precautions include proper containment to prevent contamination and adherence to local and international waste disposal guidelines to ensure safe and sustainable management of waste.