5-Fluoro-2,4(1H,3H)-pyrimidinedione

Basic Information

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CAS Number

51-21-8

Molecular Formula

C4H3FN2O2

Molecular Weight

130.08 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

282-286?°C (dec.)

Boiling Point

190-200°C/0.1mmHg

Water Solubility

12.2 g/L 20 oC

Flash Point

196.5°C

Solubility

H2O: 10 mg/mL, clear

Refractive Index

1.542

SMILES

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Fc1c[nH]c(=O)[nH]c1=O

InChI

InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChIKey

GHASVSINZRGABV-UHFFFAOYSA-N

LogP

-0.7977000000000001

Topological Polar Surface Area

65.72 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

199

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Stability

Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases.

Sensitiveness

Air Sensitive

Synonyms & References

English

Fluorouracil
1-FLUORO-1H-PYRIMIDINE-2,4-DIONE
2,4-DIHYDROXY-5-FLUOROPYRIMIDINE
5-FLUORO-1H-PYRIMIDINE-2,4-DIONE
5-FLUORO-2,4(1H,3H)-PYRIMIDINEDIONE
5-FLUORO-2,4-DIHYDROXYPYRIMIDINE
5-fluoro-2,4-pyrimidinedione
5-FLUOROPYRIMIDINE-2,4(1H,3H)-DIONE
5-Fluoropyrimidine-2,4-dione
5-FU
[180]-5-Fluorouracil
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
2,4-dioxo-5-fluoropyrimidine
3h)-pyrimidinedione,5-fluoro-4(1h
5-faracil
5-Flouracyl
5-fluor-2,4(1h,3h)-pyrimidindion
5-Fluor-2,4-dihydroxypyrimidin
5-Fluorouracil
5-Fluorouracil (5-FU, 5-Fluoracil)
Fluorouracil (5-Fluoracil, 5-FU)
2,4-Dihydroxy-5-fluoropyrimidine,5-FU,5-Fluoro-2,4(1H,3H)-pyrimidinedione
2,4-Dihydroxy-5-fluoropyriMidine
5-fluoro-2,4-dioxopyrimidine
5-fluoro-uracile
Arumel
Efudex
Efudix
Efurix
Fluri
Fluril

MDL Number

MFCD00006018

Customs Code

2933599090

FAQ

What is 5-Fluoro-2,4(1H,3H)-pyrimidinedione (CAS: 51-21-8)?

5-Fluoro-2,4(1H,3H)-pyrimidinedione is a heterocyclic organic compound with the chemical formula C4H3FN2O2. It is a derivative of pyrimidine, characterized by the presence of a fluorine atom at the 5-position and two ketone groups at the 2 and 4 positions. This compound is known for its stability and reactivity in various chemical reactions.

What are the main uses of 5-Fluoro-2,4(1H,3H)-pyrimidinedione (CAS: 51-21-8)?

This compound is primarily used in the synthesis of pharmaceuticals, particularly in the development of antiviral and anticancer drugs. It also serves as an intermediate in the production of agrochemicals and is utilized in research for its versatile chemical properties and potential biological activities.

Is 5-Fluoro-2,4(1H,3H)-pyrimidinedione (CAS: 51-21-8) safe?

5-Fluoro-2,4(1H,3H)-pyrimidinedione is generally considered safe when handled properly, but it may have toxic effects if ingested or inhaled in large quantities. It is important to follow standard safety protocols, including protective equipment and proper ventilation, during handling. Safety data sheets should be consulted for detailed guidelines.

How should 5-Fluoro-2,4(1H,3H)-pyrimidinedione (CAS: 51-21-8) be stored?

This compound should be stored in a cool, dry, and well-ventilated area, away from moisture and incompatible substances. It is typically kept in a sealed container under inert atmosphere conditions to prevent degradation. Storage should comply with local regulations and safety standards to ensure stability and safety.