(2,2-Difluorocyclopropyl)methanol

Basic Information

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CAS Number

509072-57-5

Molecular Formula

C4H6F2O

Molecular Weight

108.09 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

129°C

SMILES

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C1C(C1(F)F)CO

InChI

InChI=1S/C4H6F2O/c5-4(6)1-3(4)2-7/h3,7H,1-2H2

InChIKey

XOLSMTBBIZDHSG-UHFFFAOYSA-N

LogP

0.6338999999999999

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

81.8

Safety Information

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GHS Hazard Pictograms

H226

H315

H319

H335

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Synonyms & References

English

EN300-59739
J-506794
2,2-Difluorocyclopropylmethanol
FT-0649669
MFCD31695798
(R)-(2,2-Difluorocyclopropyl)methanol
A7539
AKOS005254700
SCHEMBL21904
AS-32926
PB42945
Cyclopropanemethanol, 2,2-difluoro-
509072-57-5
2,2-Difluoro-cyclopropanemethanol
SY344550
CS-W000392
(2,2-difluorocyclopropyl)-methanol
SY344551
SY063954
AMY17963
MFCD06797748
2,2-difluorocyclopropanemethanol
MFCD31805271
2,2-Difluorocyclopropyl methanol
DTXSID20375747
(2,2-difluoro-cyclopropyl)-methanol
(2,2-difluorocyclopropyl)methanol
(2,2-Difluorocyclopropyl)methanol
2,2-Difluorocyclopropanemethanol
(2,2-Difluorocyclopropyl)-methanol
2,2-Difluorocyclopropyl Methanol

MDL Number

MFCD06797748

Customs Code

2906199090

FAQ

What are the physical and chemical properties of (2,2-Difluorocyclopropyl)methanol (CAS: 509072-57-5)?

(2,2-Difluorocyclopropyl)methanol is a colorless liquid with a molecular weight of approximately 111.06 g/mol. It has a low solubility in water but is soluble in common organic solvents. This compound has a slightly higher boiling point compared to its cyclopropane homologue due to the presence of fluorine atoms, which contribute to its reactivity in organic synthesis. It is known for its ability to undergo various chemical transformations, making it a valuable intermediate in organic chemistry.

How is (2,2-Difluorocyclopropyl)methanol (CAS: 509072-57-5) typically synthesized?

(2,2-Difluorocyclopropyl)methanol is usually synthesized via the reductive amination of 2,2-difluorocyclopropylketone with methylamine. This process often involves the use of triphenylphosphine as a reducing agent and is performed under mild acidic conditions. Other methods include nucleophilic substitution reactions or catalytic hydrogenation of the corresponding unsaturated derivative. The yield and selectivity of these methods can vary, but they are generally efficient for laboratory and industrial-scale production.

What industries use (2,2-Difluorocyclopropyl)methanol (CAS: 509072-57-5)?

(2,2-Difluorocyclopropyl)methanol is primarily used in the pharmaceutical and fine chemical industries as a precursor in the synthesis of complex organic molecules. It is also utilized in the polymer industry for the development of new materials with specific properties. Additionally, this compound finds applications in the production of sensors and semiconductors, particularly in the electronics industry, due to its unique chemical properties and reactivity.

What precautions should be taken when handling (2,2-Difluorocyclopropyl)methanol (CAS: 509072-57-5)?

When handling (2,2-Difluorocyclopropyl)methanol, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight and flammable materials. Handling should be performed in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, it should be handled using appropriate spill kits and the material safety data sheet (SDS) should be consulted for detailed instructions. The compound should be disposed of in accordance with local regulations to ensure environmental safety.