Apixaban | CAS No. 503612-47-3

Apixaban

Basic Information

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CAS Number

503612-47-3

Molecular Formula

C25H25N5O4

Molecular Weight

459.51 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.42

SMILES

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COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N

InChI

InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)

InChIKey

QNZCBYKSOIHPEH-UHFFFAOYSA-N

LogP

2.699600000000001

Topological Polar Surface Area

110.75999999999999 Å²

Hydrogen Bond Donor/Acceptor

2 / 9

Complexity

777

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo(3,4-c)pyridine-3-carboxamide
Apixaban (JAN/USAN/INN)
1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
NSC-784102
NCGC00346555-02
NCGC00346555-05
Apixaban
GTPL6390
503612-47-3, Eliquis,
CHEMBL231779
1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[5,4-c]pyridine-3-carboxamide
Eliquis (TN)
AMY1826
s1593
CHEBI:72296
Eliquis
1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
BDBM19023
BCP02451
NS00014946
NSC784102
BCPP000396
Apixaban [USAN]
FT-0686944
APIXABAN (MART.)
1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide
1H-Pyrazolo(3,4-c)pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-
B01AF02
APIXABAN [MI]
SCHEMBL118023
AR-270/43507990

MDL Number

MFCD11977295

FAQ

What is Apixaban (CAS: 503612-47-3)?

Apixaban is an anticoagulant drug with the chemical formula C19H18N4O3S. It belongs to the class of direct oral anticoagulants (DOACs) and works by inhibiting factor Xa in the coagulation cascade. Apixaban is commonly used to prevent and treat blood clots and is available in various pharmaceutical formulations.

What are the main uses of Apixaban (CAS: 503612-47-3)?

Apixaban is primarily used to reduce the risk of stroke and systemic embolism in patients with atrial fibrillation. It is also prescribed to prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) following hip or knee replacement surgery. Additionally, Apixaban is used for the treatment of DVT and PE in adults.

Is Apixaban (CAS: 503612-47-3) safe?

Apixaban is generally considered safe when used as directed, but it may cause side effects such as bleeding, including gastrointestinal bleeding or intracranial hemorrhage. Proper handling and adherence to medical guidelines are essential. It is important to follow safety standards and consult healthcare professionals before use.

How should Apixaban (CAS: 503612-47-3) be stored?

Apixaban should be stored at room temperature (15-30°C) in a dry, light-protected place. It should be kept in a sealed container away from moisture and heat. Always check the expiration date and ensure storage conditions are appropriate to maintain its stability and potency.