Nicotinaldehyde

Basic Information

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CAS Number

500-22-1

Molecular Formula

C6H5NO

Molecular Weight

107.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Yellow to Brown Liquid

Melting Point

8°C

Boiling Point

97°C/15mmHg

Water Solubility

miscible

Refractive Index

n20/D 1.549(lit.)

SMILES

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O=Cc1cccnc1

InChI

InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H

InChIKey

QJZUKDFHGGYHMC-UHFFFAOYSA-N

LogP

0.8940999999999999

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

82.6

Safety Information

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GHS Hazard Pictograms

H226

H302

H315

H317

H318

H335

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Sensitiveness

Air Sensitive

Synonyms & References

English

3-Pyridinecarboxaldehyde
AURORA KA-3059
NICOTINALDEHYDE
PYRIDINE-3-ALDEHYDE
PYRIDINE-3-CARBALDEHYDE
PYRIDINE-3-CARBOXALDEHYDE
TIMTEC-BB SBB004359
3-Formylpyridine
3-Nicotinaldehyde
3-Pyridinaldehyde
3-Pyridinealdehyde
3-Pyridylaldehyde
3-Pyridylcarboxaldehyde
3-Pyridylcarboxaldehyde DEG
beta-Pyridinecarbonaldehyde
Nicotinealdehyde
Nicotinic aldehyde
3-Pyridinecarboxalde
3-Pyridinemethanol or 3-pyridinecarboxaldehyde or nicotinaldehyde
3-Pyridinecarbaldeh
3-Pyridylaldehyde
Nicotinaldehyde
Pyridine-3-carboxaldehyde
pyridine-3-carbaldehyde

MDL Number

MFCD00006382

Customs Code

29333999

FAQ

What is Nicotinaldehyde (CAS: 500-22-1)?

Nicotinaldeyde (CAS: 500-22-1) is a chemical compound with the formula C6H5NO2. It is a colorless liquid characterized by a sharp, aldehyde-like odor. The compound contains a pyridine ring with an aldehyde group, making it a key intermediate in various chemical processes. It is soluble in ethanol and ether, with a boiling point of approximately 240°C.

What are the main uses of Nicotinaldehyde (CAS: 500-22-1)?

Nicotinaldehyde (CAS: 500-22-1) is widely used in pharmaceuticals as a precursor for vitamin B3 derivatives and antidiabetic drugs. It also serves in the food industry as a flavor enhancer and in research for studying nicotinic acid analogs. Additionally, it is applied in industrial organic synthesis and as a reagent in chemical manufacturing processes.

Is Nicotinaldehyde (CAS: 500-22-1) safe?

Nicotinaldehyde (CAS: 500-22-1) is toxic if inhaled or ingested and may cause skin and eye irritation. Safety guidelines recommend handling with appropriate PPE, such as gloves and goggles, and working in well-ventilated areas. It is classified as a hazardous substance under OSHA and EPA regulations, requiring careful adherence to safety protocols to minimize risk.

How should Nicotinaldehyde (CAS: 500-22-1) be stored?

Nicotinaldehyde (CAS: 500-22-1) should be stored in a sealed, airtight container in a cool (2-8°C), dry, and dark location. It is sensitive to air and moisture, so storage away from these elements is critical. Keep in a well-ventilated area to prevent vapor accumulation, and ensure it is protected from light to maintain stability and prevent degradation.