2'-Deoxy-5-fluorouridine

Basic Information

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CAS Number

50-91-9

Molecular Formula

C9H11FN2O5

Molecular Weight

246.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

148?°C

Boiling Point

150 °C

Water Solubility

soluble

Refractive Index

1.608

Specific Rotation

35.9 º (c=1, water)

SMILES

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C1C(C(OC1N2C=C(C(=O)NC2=O)F)CO)O

InChI

InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChIKey

ODKNJVUHOIMIIZ-RRKCRQDMSA-N

LogP

-1.6835999999999995

Topological Polar Surface Area

104.54999999999998 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

386

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Stability

Stable. Incompatible with strong oxidizing agents.

Sensitiveness

thermally sensitive

Synonyms & References

English

DB00322
C9H11FN2O5
FLOXURIDINE [ORANGE BOOK]
beta-5-Fluoro-2'-deoxyuridine
5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
NSC27640
HSDB 3227
Deoxyfluorouridine
(+)-5-fluoro-2'-deoxyuridine
Epitope ID:138108
BCP02871
ODKNJVUHOIMIIZ-RRKCRQDMSA-N
FLOXURIDINE [INN]
BRN 0090221
NSC 27640
NCGC00023722-08
2'-deoxy-5-fluoro uridine
HMS3715A11
MLS002695934
Z756475348
CHEMBL917
Floxuridine,(S)
Q5462356
LS-160820
CS-1827
Floxuridinum
s1299
1-[(4S,2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,3-dihydropyri midine-2,4-dione
Opera_ID_1559
NCGC00023722-03
Floxuridine (USP/INN)

MDL Number

MFCD01547663

Customs Code

2934999090

FAQ

What is 2'-Deoxy-5-fluorouridine (CAS: 50-91-9)?

2'-Deoxy-5-fluorouridine (CAS: 50-91-9) is an antiviral and antineoplastic medication used in the treatment of AIDS-related opportunistic infections and certain types of cancer. It is a modified version of uridine with a 2'-deoxy and 5-fluoro substitution.

What are the main uses of 2'-Deoxy-5-fluorouridine (CAS: 50-91-9)?

2'-Deoxy-5-fluorouridine is primarily used in the treatment of AIDS-related Pneumocystis jirovecii pneumonia (PCP) and as an adjunct in the treatment of acute myeloid leukemia (AML) and other types of cancer. It is also used in combination with other antiviral and chemotherapy agents.

Is 2'-Deoxy-5-fluorouridine (CAS: 50-91-9) safe?

2'-Deoxy-5-fluorouridine can be toxic and may cause side effects such as nausea, vomiting, and bone marrow suppression. It should be handled with care and only by trained medical professionals. Proper protective measures include wearing gloves, goggles, and a lab coat. Storage and disposal must comply with local regulations.

How should 2'-Deoxy-5-fluorouridine (CAS: 50-91-9) be stored?

2'-Deoxy-5-fluorouridine should be stored in a tightly sealed container at room temperature (15-30°C) away from light and moisture. It should be kept out of reach of children and pets. Ensure that the storage area is well-ventilated and that the containers are clearly labeled with the CAS number and contents. Follow local regulations for the disposal of unused or expired products.