Lamotrigine EP Impurity E (Lamotrigine USP Related Compound B)

Basic Information

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CAS Number

50-45-3

Molecular Formula

C7H4Cl2O2

Molecular Weight

191.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

168-170?°C

Boiling Point

306.9°C at 760 mmHg

Water Solubility

slightly soluble

Flash Point

139.4°C

Refractive Index

1.4590 (estimate)

Vapor Pressure

0.000326mmHg at 25°C

SMILES

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C1=CC(=C(C(=C1)Cl)Cl)C(=O)O

InChI

InChI=1S/C7H4Cl2O2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,(H,10,11)

InChIKey

QAOJBHRZQQDFHA-UHFFFAOYSA-N

LogP

2.691600000000001

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

161

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

FT-0609556
AI3-33364
2,3-Dichlorobenzoic acid, pharmaceutical impurity standard
2,3-Dichloro benzoic acid
STR00916
LS-1305
1126107-18-3
InChI=1/C7H4Cl2O2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,(H,10,11
2,3-dichlorobenzoate;2,3-Dichlorobenzoic acid
MFCD00002413
EINECS 200-039-5
Benzoic acid, dichloro-
CS-M-02269
EC 200-039-5
2,3-Dichlorobenzoic acid, 97%
SY023164
Lamotrigine Impurity E
EN300-17210
50-45-3
LAMOTRIGINE IMPURITY E [EP IMPURITY]
CGP39QV5WF
2,3-Dichorobenzoic acid
2,3 dichlorobenzoic acid
STL195584
AM81265
NCGC00091187-02
D3319
2,3-dichloro-benzoic acid
UNII-CGP39QV5WF
NCGC00258741-01
BRN 1946217

MDL Number

MFCD00002413

Customs Code

2916399090

FAQ

What is Lamotrigine EP Impurity E (CAS: 50-45-3)?

Lamotrigine EP Impurity E (Lamotrigine USP Related Compound B), with CAS number 50-45-3, is a structural impurity associated with lamotrigine, an anticonvulsant medication. It is chemically related to lamotrigine (C13H12N2O2S) and may arise during synthesis or degradation. This compound is typically analyzed in pharmaceutical quality control to ensure drug purity and safety.

What are the main uses of Lamotrigine EP Impurity E (CAS: 50-45-3)?

Lamotrigine EP Impurity E (Lamotrigine USP Related Compound B) is primarily used in pharmaceutical research and quality control to identify and quantify impurities in lamotrigine preparations. It also serves as a reference standard for analytical methods, such as HPLC, to assess drug purity and compliance with regulatory specifications.

Is Lamotrigine EP Impurity E (CAS: 50-45-3) safe?

Lamotrigine EP Impurity E (Lamotrigine USP Related Compound B) is generally considered safe when present within acceptable limits in pharmaceutical products, as per regulatory guidelines. However, direct handling should follow standard safety protocols, including PPE use and adherence to safety data sheets. Its toxicity profile is less well-documented compared to the parent compound, lamotrigine.

How should Lamotrigine EP Impurity E (CAS: 50-45-3) be stored?

Lamotrigine EP Impurity E (Lamotrigine USP Related Compound B) should be stored in a cool, dry place (2-8°C), protected from light, and in a sealed container to maintain stability. Avoid exposure to moisture and humidity above 60%. Proper storage ensures its integrity as a reference standard for analytical testing.