3-Chloro-5-nitro-1H-indazole | CAS No. 4812-45-7
3-Chloro-5-nitro-1H-indazole
Basic Information
CAS Number
4812-45-7
Molecular Formula
C7H4ClN3O2
Molecular Weight
197.58 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
218-220
Boiling Point
234.7℃ at 760 mmHg
Safety Information
View Safety InformationHazard Statement
Hazard Class
Class IRRITANT
Class IRRITANT
Synonyms & References
English
- SY020588
- PB23162
- EINECS 225-380-7
- AKOS005072371
- Indazole, 3-chloro-5-nitro-
- BRN 0013635
- 4812-45-7
- EN300-97377
- NSC-108652
- 3-Chloro-5-nitroindazole
- NSC108652
- 1H-Indazole, 3-chloro-5-nitro-
- Chloro-3 nitro-5 indazole [French]
- AMY26996
- DTXSID80197427
- 2-23-00-00151 (Beilstein Handbook Reference)
- Chloro-3 nitro-5 indazole
- EA-0864
- NSC 108652
- 3-CHLORO-5-NITRO-INDAZOLE
- 3-Chloro-5-nitro-1H-indazole
- 3-chloro-5-nitro-2H-indazole
- J-512282
- FT-0635450
- MFCD00005692
- SCHEMBL760760
- A871950
- NS00031765
- 1H-INDAZOLE,3-CHLORO-5-NITRO
- 1H-Indazole,3-chloro-5-nitro-
- 3-Chloro-5-nitro (1H)indazole
MDL Number
MFCD00005692
FAQ
What are the physical and chemical properties of 3-Chloro-5-nitro-1H-indazole (CAS: 4812-45-7)?
3-Chloro-5-nitro-1H-indazole is a crystalline solid with a molecular weight of approximately 228.57 g/mol. It is only slightly soluble in water but soluble in common organic solvents like ethanol and acetone. The compound is known for its high reactivity towards nucleophiles and can undergo substitution reactions easily. It is a yellowish to orange crystalline solid at room temperature.
How is 3-Chloro-5-nitro-1H-indazole (CAS: 4812-45-7) typically synthesized?
3-Chloro-5-nitro-1H-indazole can be synthesized via the nitration of 3-chloro-1H-indazole followed by the removal of the hydroxyl group. Commonly, this involves refluxing 3-chloro-1H-indazole with nitric acid in the presence of sulfuric acid. The yield of the reaction is typically around 75-85%, with careful control of reaction conditions to achieve high selectivity and purity.
What industries use 3-Chloro-5-nitro-1H-indazole (CAS: 4812-45-7)?
3-Chloro-5-nitro-1H-indazole is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also utilized in the polymer industry for the production of specific types of polymers, and in the sensor industry for developing gas sensors. Its electronic properties make it a potential candidate for use in semiconductors and optoelectronic devices.
What precautions should be taken when handling 3-Chloro-5-nitro-1H-indazole (CAS: 4812-45-7)?
When handling 3-Chloro-5-nitro-1H-indazole, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood due to its reactive nature. Spills should be cleaned up carefully using appropriate absorbents, and the area should be properly ventilated. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.
Related Compounds
![[1-(2-Pyrazinylmethyl)-4-piperidinyl]methanol structure](https://static.chemtradehub.com/structs/124/1247703-29-2-3e8f.webp "[1-(2-Pyrazinylmethyl)-4-piperidinyl]methanol structure")
![(2S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-1-propanol structure](https://static.chemtradehub.com/structs/139/139264-69-0-da9c.webp "(2S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-1-propanol structure")
(2S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-1-propanol
CAS Number:
139264-69-0
Molecular Formula:
C15H23N3O
![2-[(1S)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1) structure](https://static.chemtradehub.com/structs/143/1431511-18-0-164b.webp "2-[(1S)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1) structure")
2-[(1S)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1)
CAS Number:
1431511-18-0
Molecular Formula:
C30H41NO7
![3-Methyl-1,3-dihydro-2H-imidazo[4,5-f]quinolin-2-one structure](https://static.chemtradehub.com/structs/144/144486-08-8-1df1.webp "3-Methyl-1,3-dihydro-2H-imidazo[4,5-f]quinolin-2-one structure")
3-Methyl-1,3-dihydro-2H-imidazo[4,5-f]quinolin-2-one
CAS Number:
144486-08-8
Molecular Formula:
C11H9N3O
![(1aS,1bS,6bS,7aS,8aS,9R,10S,11S,11aS)-9,10,11-Trihydroxy-10-isopropyl-1b-methyl-1b,3,6,6b,7,7a,9,10,11,11a-decahydrobisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one structure](https://static.chemtradehub.com/structs/147/147852-78-6-0a74.webp "(1aS,1bS,6bS,7aS,8aS,9R,10S,11S,11aS)-9,10,11-Trihydroxy-10-isopropyl-1b-methyl-1b,3,6,6b,7,7a,9,10,11,11a-decahydrobisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one structure")
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