Compound Q&A
How is (1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide 2,2,2-trifluoroacetate (CAS: 700376-58-5) typically synthesized?
Answer
![(1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide 2,2,2-trifluoroacetate](https://static.chemtradehub.com/structs/700/700376-58-5-94b3.webp "(1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide 2,2,2-trifluoroacetate")
(1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide 2,2,2-trifluoroacetate is typically synthesized via a multistep process involving the synthesis of the azabicyclic core and subsequent amidation with trifluoroacetic acid. Commonly, this involves protecting group strategies and catalytic hydrogenation, yielding a high purity product with a yield of around 60-70%.
About
CAS No
700376-58-5
English Name
(1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide 2,2,2-trifluoroacetate
Molecular Formula
C8H11F3N2O3
Molecular Weight
240.18099999999998 g/mol
SMILES
O=C([C@H]1N[C@]2([H])C[C@]2([H])C1)N.O=C(O)C(F)(F)F
InChIKey
ANTLFTRMIBAQHA-ZDQHTEEMSA-N
Last Updated: 2026-03-11 12:33
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