Compound Q&A
How is 3-Chloro-5-nitro-1H-indazole (CAS: 4812-45-7) typically synthesized?
Answer
3-Chloro-5-nitro-1H-indazole can be synthesized via the nitration of 3-chloro-1H-indazole followed by the removal of the hydroxyl group. Commonly, this involves refluxing 3-chloro-1H-indazole with nitric acid in the presence of sulfuric acid. The yield of the reaction is typically around 75-85%, with careful control of reaction conditions to achieve high selectivity and purity.
About
CAS No
4812-45-7
English Name
3-Chloro-5-nitro-1H-indazole
Molecular Formula
C7H4ClN3O2
Molecular Weight
197.58 g/mol
SMILES
C1=CC2=NNC(=C2C=C1[N+](=O)[O-])Cl
InChIKey
UOWPRWCAMGTPHI-UHFFFAOYSA-N
Last Updated: 2025-10-28 15:15
