1-Piperidinol | CAS No. 4801-58-5

1-Piperidinol

Basic Information

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CAS Number

4801-58-5

Molecular Formula

C5H11NO

Molecular Weight

101.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

37-39 °C

Boiling Point

146-148 ºC (1 Torr)

Refractive Index

1.4550 (estimate)

SMILES

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ON1CCCCC1

InChI

InChI=1S/C5H11NO/c7-6-4-2-1-3-5-6/h7H,1-5H2

InChIKey

LKPFBGKZCCBZDK-UHFFFAOYSA-N

LogP

0.8614999999999999

Topological Polar Surface Area

23.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

Safety Information

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GHS Hazard Pictograms

H225

Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

Sensitiveness

对湿度敏感

Synonyms & References

English

Piperidin-1-ol
1-Hydroxypiperidine
n-hydroxypiperidine
1-hydroxy-piperidin
1-Piperidinol
1-hydroxypiperidine
N-Hydroxypiperidine

MDL Number

MFCD00038048

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 1-Piperidinol (CAS: 4801-58-5)?

1-Piperidinol (CAS: 4801-58-5) is a colorless liquid with a bitter taste. It has a molecular weight of approximately 109.18 g/mol. The compound is moderately soluble in water and highly soluble in ethanol. Chemically, it is an amine derivative and can react with various electrophiles. It is also known for its basic nature and can form complexes with certain metal ions.

How is 1-Piperidinol (CAS: 4801-58-5) typically synthesized?

1-Piperidinol (CAS: 4801-58-5) is typically synthesized via reduction of piperidine using sodium borohydride or lithium aluminum hydride. The reaction involves the reduction of the piperidine ring to form the alcohol. The process is conducted under inert atmosphere to prevent oxidation and is known for its good yield and selectivity.

What industries use 1-Piperidinol (CAS: 4801-58-5)?

1-Piperidinol (CAS: 4801-58-5) is utilized in various industries. It is an intermediate in the synthesis of pharmaceuticals, particularly as a precursor for antihistamines and antipsychotics. Additionally, it is used in the polymer industry as a monomer and in the production of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 1-Piperidinol (CAS: 4801-58-5)?

When handling 1-Piperidinol (CAS: 4801-58-5), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a well-ventilated area and away from oxidizing agents. In case of a spill, it should be cleaned up using appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.