Plecanatide | CAS No. 467426-54-6

Plecanatide

Basic Information

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CAS Number

467426-54-6

Molecular Formula

C65H104N18O26S4

Molecular Weight

1681.89 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Amorphous, white to off-white powder

SMILES

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S1C[C@@]2([H])C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@]([H])(C(N[C@]([H])(C(NCC(N[C@H](C(N[C@H](C(=O)O)CC(C)C)=O)CS1)=O)=O)[C@@H](C)O)=O)CSSC[C@@H](C(N[C@@H](CCC(=O)O)C(N[C@H](C(N2)=O)CC(C)C)=O)=O)NC([C@H](CCC(=O)O)NC([C@H](CC(=O)O)NC([C@H](CC(N)=O)N)=O)=O)=O)=O)=O)C(C)C)=O)=O)C(C)C)=O

InChI

1S/C65H104N18O26S4/c1-25(2)15-34-55(98)80-41-24-113-110-21-38(58(101)77-37(65(108)109)16-26(3)4)71-44(87)20-69-62(105)50(30(10)84)83-61(104)40(78-51(94)29(9)70-63(106)48(27(5)6)81-57(100)35(18-43(68)86)76-64(107)49(28(7)8)82-60(41)103)23-112-111-22-39(59(102)73-32(53(96)75-34)11-13-45(88)89)79-54(97)33(12-14-46(90)91)72-56(99)36(19-47(92)93)74-52(95)31(66)17-42(67)85/h25-41,48-50,84H,11-24,66H2,1-10H3,(H2,67,85)(H2,68,86)(H,69,105)(H,70,106)(H,71,87)(H,72,99)(H,73,102)(H,74,95)(H,75,96)(H,76,107)(H,77,101)(H,78,94)(H,79,97)(H,80,98)(H,81,100)(H,82,103)(H,83,104)(H,88,89)(H,90,91)(H,92,93)(H,108,109)/t29-,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,48-,49-,50-/m0/s1

InChIKey

NSPHQWLKCGGCQR-DLJDZFDSSA-N

LogP

-8.148299999999962

Topological Polar Surface Area

718.1300000000002 Å²

Hydrogen Bond Donor/Acceptor

26 / 44

Complexity

3490

Synonyms & References

English

L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-Glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-leucine cyclic (4→12),(7→15)-bis(disulfide)
SP 304
Trulance
Plecanatide
7IK8Z952OK
Plecanatide [USAN:INN]
Guanilib
GTPL9069
DB13170
[3-glutamic acid(D>E)]human uroguanylin
(3-Glutamic acid(D>E))human uroguanylin (UGN)

FAQ

What is Plecanatide (CAS: 467426-54-6)?

Plecanatide is a synthetic cyclic nonapeptide used in the treatment of chronic idiopathic constipation and chronic constipation associated with hypokalemia. It has a molecular formula of C63H94N14O14 and is known for its ability to target the GC-C receptor in the intestine, promoting fluid secretion and enhancing bowel movements.

What are the main uses of Plecanatide (CAS: 467426-54-6)?

Plecanatide is primarily used to treat chronic idiopathic constipation and chronic constipation in patients with hypokalemia. It has also shown potential in managing other gastrointestinal disorders, though its use in these conditions is not yet widespread.

Is Plecanatide (CAS: 467426-54-6) safe?

Plecanatide is generally considered safe when used as directed. However, it is important to follow the prescribed dosage and monitor for any adverse reactions. Patients should consult their healthcare provider if they experience any unusual symptoms or side effects.

How should Plecanatide (CAS: 467426-54-6) be stored?

Plecanatide should be stored at room temperature between 15-30°C (59-86°F) and protected from light. It should be kept in a tightly sealed container to prevent moisture and should not be exposed to extreme temperatures or humidity to ensure its efficacy and safety.