3-Piperidinylmethanol

Basic Information

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CAS Number

4606-65-9

Molecular Formula

C6H13NO

Molecular Weight

115.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

59.0 to 64.0 deg-C

Boiling Point

107°C/3.5mmHg

Refractive Index

1.494

SMILES

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C1CC(CNC1)CO

InChI

InChI=1S/C6H13NO/c8-5-6-2-1-3-7-4-6/h6-8H,1-5H2

InChIKey

VUNPWIPIOOMCPT-UHFFFAOYSA-N

LogP

-0.02170000000000022

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

65.5

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Hygroscopic

Synonyms & References

English

AC-22476
AM100839
MFCD09751036
SY067329
J-502110
4606-65-9
3-hydroxymethyl-piperidine
VUNPWIPIOOMCPT-UHFFFAOYSA-
FT-0649811
3-hydroxymethyl piperidine
NS00048825
(+/-)-piperidin-3-yl-methanol
EINECS 225-013-0
Piperidin-3-Yl-Methanol
SCHEMBL213201
LF-0536
piperidine-3-yl-methanol
racemic 3-piperidinemethanol
racemic piperidin-3-methanol
3-Piperidinemethanol, 96%
DTXSID60871091
FT-0649793
H0737
3-Piperidinylmethanol
Piperidin-3-yl methanol
Q-102742
Piperidin-3-ylmethanol
SY027077
(R)-3-Piperidinemethanol
3-Piperidinemethanol
MFCD00005997

MDL Number

MFCD00005997

FAQ

What are the physical and chemical properties of 3-Piperidinylmethanol (CAS: 4606-65-9)?

3-Piperidinylmethanol (CAS: 4606-65-9) is a colorless liquid with a refractive index of 1.50 and a specific gravity of 0.952. It has a molecular weight of 125.19 g/mol and a melting point of -28°C. It is slightly soluble in water but soluble in organic solvents such as ethanol and acetone. It is chemically reactive, particularly towards nucleophiles, and can undergo substitution and condensation reactions.

How is 3-Piperidinylmethanol (CAS: 4606-65-9) typically synthesized?

3-Piperidinylmethanol (CAS: 4606-65-9) can be synthesized via the nucleophilic substitution of piperidine with methanol. Common methods include the use of sodium methoxide in aprotic solvents like dimethylformamide (DMF) under basic conditions. The reaction is known for its high yield and good selectivity, making it suitable for industrial scale-up.

What industries use 3-Piperidinylmethanol (CAS: 4606-65-9)?

3-Piperidinylmethanol (CAS: 4606-65-9) finds applications in pharmaceuticals for the synthesis of various APIs and intermediates. It is also used in polymer chemistry for modifying properties of polymers. Additionally, it is employed in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 3-Piperidinylmethanol (CAS: 4606-65-9)?

When handling 3-Piperidinylmethanol (CAS: 4606-65-9), ensure proper personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work in a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.