3-Piperidinylmethanol(CAS: 4606-65-9)

3-Piperidinylmethanol (CAS: 4606-65-9) is a colorless liquid with a refractive index of 1.50 and a specific gravity of 0.952. It has a molecular weight of 125.19 g/mol and a melting point of -28°C. It is slightly soluble in water but soluble in organic solvents such as ethanol and acetone. It is chemically reactive, particularly towards nucleophiles, and can undergo substitution and condensation reactions.

3-Piperidinylmethanol (CAS: 4606-65-9) can be synthesized via the nucleophilic substitution of piperidine with methanol. Common methods include the use of sodium methoxide in aprotic solvents like dimethylformamide (DMF) under basic conditions. The reaction is known for its high yield and good selectivity, making it suitable for industrial scale-up.

3-Piperidinylmethanol (CAS: 4606-65-9) finds applications in pharmaceuticals for the synthesis of various APIs and intermediates. It is also used in polymer chemistry for modifying properties of polymers. Additionally, it is employed in the development of sensors and semiconductors due to its unique chemical properties.

When handling 3-Piperidinylmethanol (CAS: 4606-65-9), ensure proper personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work in a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.