6-Chloro-2-pyridinamine

Basic Information

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CAS Number

45644-21-1

Molecular Formula

C5H5ClN2

Molecular Weight

128.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

69-73 °C

Boiling Point

255.7°C at 760 mmHg

Density

1.3260

Flash Point

108.5℃

Refractive Index

1.607

Vapor Pressure

0.0±0.5 mmHg at 25°C

SMILES

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C1=CC(=NC(=C1)Cl)N

InChI

InChI=1S/C5H5ClN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)

InChIKey

OBYJTLDIQBWBHM-UHFFFAOYSA-N

LogP

1.3172

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

76.8

Safety Information

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GHS Hazard Pictograms

H302

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Amino-6-chloropyridine (6-Chloropyridin-2-ylamine)
OBYJTLDIQBWBHM-UHFFFAOYSA-N
PB26011
BRN 0108669
2-Pyridinamine, 6-chloro-
6-Chloro-2-pyridinamine
DTXSID20196575
CS-W002551
A7183
Pyridine, 2-amino-6-chloro-
6-chloro-pyridin-2-ylamine
SY003744
MFCD00234068
45644-21-1
AC-1411
AC-907/25004401
6-chloropyridin-2-amine
AM20070061
BCP22216
PS-5492
6-chloro-2-pyridinylamine
2-Amino-6-chloropyridine
CL0045
2-Chloro-6-aminopyridine
4-22-00-04028 (Beilstein Handbook Reference)
AKOS000275942
6-chloropyridin-2-ylamine
6-Amino-2-chloropyridine
2-Amino-6-chloropyridine, 97%
EN300-86280
2-chloro-6-amino-pyridine

MDL Number

MFCD00234068

Customs Code

2933399090

FAQ

What is 6-Chloro-2-pyridinamine (CAS: 45644-21-1)?

6-Chloro-2-pyridinamine (CAS: 45644-21-1) is a chlorinated pyridine derivative with the chemical formula C5H5ClN. It is a white crystalline solid with a moderately polar character and is commonly used as an intermediate in organic synthesis. The compound features a pyridine ring with a chlorine atom at the 6-position and an amino group at the 2-position, making it relevant in pharmaceutical and research applications.

What are the main uses of 6-Chloro-2-pyridinamine (CAS: 45644-21-1)?

6-Chloro-2-pyridinamine (CAS: 45644-21-1) is primarily used in the pharmaceutical industry as a precursor for developing drugs targeting neurological disorders. It also serves in chemical synthesis for creating agrochemicals, dyes, and other specialty chemicals. Its unique structure makes it valuable in research for functional group modifications and drug molecule design.

Is 6-Chloro-2-pyridinamine (CAS: 45644-21-1) safe?

6-Chloro-2-pyridinamine (CAS: 45644-21-1) has a toxicity profile that requires careful handling. While it is generally considered low to moderately toxic, direct contact may cause skin or eye irritation. Safety measures include wearing protective gloves, goggles, and ensuring adequate ventilation. Always follow OSHA and EPA guidelines for safe use and disposal.

How should 6-Chloro-2-pyridinamine (CAS: 45644-21-1) be stored?

6-Chloro-2-pyridinamine (CAS: 45644-21-1) should be stored in a cool, dry place (ideally 25°C), away from light and moisture. Keep in a sealed, airtight container to maintain stability. Avoid exposure to incompatible substances and ensure proper labeling to prevent contamination or accidental use.