2-Chloro-1-(4-fluorophenyl)ethanone

Basic Information

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CAS Number

456-04-2

Molecular Formula

C8H6ClFO

Molecular Weight

172.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

48.0 to 52.0 deg-C

Boiling Point

247°C

Water Solubility

Insoluble in water.

SMILES

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C1=CC(=CC=C1C(=O)CCl)F

InChI

InChI=1S/C8H6ClFO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2

InChIKey

UJZWJOQRSMOFMA-UHFFFAOYSA-N

LogP

2.2472000000000003

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

141

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Lachrymatory

Synonyms & References

English

4-07-00-00642 (Beilstein Handbook Reference)
W-106123
SCHEMBL455101
EINECS 207-256-4
2-chloro-4'-fluoro-acetophenone
456-04-2
BDBM50119680
AKOS000120174
.alpha.-Chloro-para-fluoroacetophenone
4-chloroacetyl-1-fluorobenzene
2-chloro-1-(4'-fluorophenyl)ethanone
PD140506
2-chloro-1-(4-fluorophenyl)-1-ethanone
CS-W017579
2-Chloro-1-(4-fluorophenyl)ethanone
BRN 0637860
2-Chloro-4'-fluoroacetophenone, 99%
AM20040509
2-Cl-4'-F-acetophenone
A7181
F0001-1236
2-chloro-1-(4-fluorophenyl)ethanone;2-Chloro-4'-fluoroacetophenone
PIPERIDIN-4-YL-UREAHCL
DTXSID70196560
p-Fluoro-.alpha.-chloroacetophenone
.alpha.-Chloro-p-fluoroacetophenone
2-chloro-1-(4-fluorophenyl)-ethanone
Z104478978
A-Chloro-p-Fluoro acetophenone
C1977

MDL Number

MFCD00011652

Customs Code

2914700090

FAQ

What regulatory guidelines apply to 2-Chloro-1-(4-fluorophenyl)ethanone (CAS: 456-04-2)?

2-Chloro-1-(4-fluorophenyl)ethanone (CAS: 456-04-2) falls under the scope of regulatory guidelines such as GHS for classification and labeling. It is also subject to REACH regulations in the European Union, requiring registration and reporting of its safety data. In the USA, it must comply with FDA and EPA regulations, including environmental protection and safe handling practices. Proper storage and disposal must follow these guidelines to ensure compliance.

Are there alternatives to 2-Chloro-1-(4-fluorophenyl)ethanone (CAS: 456-04-2) in synthesis?

In synthesis, alternatives to 2-Chloro-1-(4-fluorophenyl)ethanone (CAS: 456-04-2) include using similar compounds like 2-Bromo-1-(4-fluorophenyl)ethanone or 2-Iodo-1-(4-fluorophenyl)ethanone, which may offer similar reactivity with different substitution patterns. Additionally, using more environmentally friendly reagents like triphenylphosphine or other Lewis acids could be considered as alternatives.

What is the market or research trend for 2-Chloro-1-(4-fluorophenyl)ethanone (CAS: 456-04-2)?

The market trend for 2-Chloro-1-(4-fluorophenyl)ethanone (CAS: 456-04-2) is driven by its applications in pharmaceuticals and pesticides due to its versatile reactivity. Research trends focus on optimizing synthesis methods and exploring its use in new chemical reactions. As demand for more sustainable and environmentally friendly chemicals grows, there is an increasing interest in alternative compounds and greener synthetic routes.

How should waste containing 2-Chloro-1-(4-fluorophenyl)ethanone (CAS: 456-04-2) be handled?

Waste containing 2-Chloro-1-(4-fluorophenyl)ethanone (CAS: 456-04-2) should be collected in appropriate containers labeled with hazard information. It should be stored separately and disposed of according to local regulations, typically through incineration or professional waste disposal services. Environmental precautions include minimizing exposure and ensuring compliance with GHS, REACH, and other relevant regulations to protect health and the environment.