2-Fluoro-4-methoxy-1-nitrobenzene

Basic Information

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CAS Number

446-38-8

Molecular Formula

C7H6FNO3

Molecular Weight

171.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

57~63°C

Boiling Point

264.5℃ at 760 mmHg

SMILES

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COC1=CC(=C(C=C1)[N+](=O)[O-])F

InChI

InChI=1S/C7H6FNO3/c1-12-5-2-3-7(9(10)11)6(8)4-5/h2-4H,1H3

InChIKey

PLEJCMKVJYUUBA-UHFFFAOYSA-N

LogP

2.26570

Complexity

171

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 8 Class 8

Synonyms & References

English

Benzene, 2-fluoro-4-methoxy-1-nitro-
2-Fluoro-4-methoxynitrobenzene
3-fluoro-4-nitroanisol
EN300-120099
FT-0632141
SCHEMBL6520
2-Fluoro-4-methoxy-1-nitrobenzene #
2-Fluoro-4-(methoxy)-1-nitrobenzene
3-fluoro-4-nitro-anisol
AKOS009492953
BCP21579
5-methoxy-2-nitrofluorobenzene
AM61985
446-38-8
DTXSID10340560
3-fluoro-4-nitroanisole, AldrichCPR
3-Fluoro-4-nitrophenyl methyl ether
4-Methoxy-2-fluoro-1-nitrobenzene
2-fluoro-4-methoxy-1-nitro-benzene
MFCD04115632
F1291
J-512501
SCHEMBL19058467
CS-D1687
446-38-8a
2-Fluoro-4-methoxy-1-nitrobenzene
A19870
A7242
Nitrobenzene,-2-fluoro,-4-methoxy
3-Fluoro-4-nitroanisole
AC-3806

MDL Number

MFCD04115632

Customs Code

2909309090

FAQ

What are the physical and chemical properties of 2-Fluoro-4-methoxy-1-nitrobenzene (CAS: 446-38-8)?

2-Fluoro-4-methoxy-1-nitrobenzene is a crystalline solid with a molecular weight of approximately 217.06 g/mol. It is sparingly soluble in water but miscible with organic solvents like ethanol and acetone. Chemically, it is relatively stable but can undergo nitro reduction and fluorine substitution reactions. It is an important intermediate in the synthesis of various pharmaceuticals and dyes.

How is 2-Fluoro-4-methoxy-1-nitrobenzene (CAS: 446-38-8) typically synthesized?

2-Fluoro-4-methoxy-1-nitrobenzene can be synthesized via the nitration of 2-fluoro-4-methoxybenzene with concentrated nitric acid in the presence of sulfuric acid as a catalyst. The reaction is carried out under reflux, and the yield is around 70-80%. Selectivity and purity can be improved through careful control of reaction conditions.

What industries use 2-Fluoro-4-methoxy-1-nitrobenzene (CAS: 446-38-8)?

2-Fluoro-4-methoxy-1-nitrobenzene is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs, particularly those involving aromatic nitro groups. It also finds applications in the synthesis of dyes and pigments, and as a precursor in the electronics industry for producing organic semiconductors and sensors.

What precautions should be taken when handling 2-Fluoro-4-methoxy-1-nitrobenzene (CAS: 446-38-8)?

When handling 2-Fluoro-4-methoxy-1-nitrobenzene, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of fumes. Store the compound under a nitrogen atmosphere to prevent oxidation. In case of spills, neutralize with an appropriate solution and dispose of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed handling and storage information.