Beclomethasone

Basic Information

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CAS Number

4419-39-0

Molecular Formula

C22H29ClO5

Molecular Weight

408.9 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Melting Point

234-237 ºC

SMILES

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CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)Cl)C

InChI

InChI=1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChIKey

NBMKJKDGKREAPL-DVTGEIKXSA-N

LogP

2.165

Topological Polar Surface Area

94.83000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

805

Synonyms & References

English

CHEBI:3001
SR-01000000273-4
4419-39-0
CHEMBL1586
NCGC00164402-01
9alpha-Chloro-11beta,17alpha,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
Beclometasone (INN)
CS-5872
(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS-4419-39-0
SMR000058899
EINECS 224-585-9
A07EA07
Beclometason
Beclometason (TN)
KGZ1SLC28Z
D07AC15
F85436
Tox21_112116
9-CHLORO-11.BETA.,17,21-TRIHYDROXY-16.BETA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE
HMS2233A18
pulvinal
AMY7469
BDBM53488
EX-A4423
NBMKJKDGKREAPL-DVTGEIKXSA-N
Beclometasonum [INN-Latin]
Beclometasone-17-Propionate
(8~{S},9~{R},10~{S},11~{S},13~{S},14~{S},16~{S},17~{R})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
MFCD00135614
UNII-KGZ1SLC28Z

MDL Number

MFCD00135614

FAQ

What regulatory guidelines apply to Beclomethasone (CAS: 4419-39-0)?

Beclomethasone (CAS: 4419-39-0) is a steroid medication that falls under various regulatory guidelines. It must comply with Good Manufacturing Practices (GMP) and be registered under the REACH regulations in the EU. In the US, it should be registered with the FDA and adhere to EPA regulations regarding its environmental handling. Additionally, it should meet the criteria for handling and storage as outlined by the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).

Are there alternatives to Beclomethasone in synthesis?

Beclomethasone (CAS: 4419-39-0) can be synthesized using various methods. For instance, alternative reagents such as 17α-acetylene can be used instead of 17α-acetylation. Other analogs like fluticasone propionate can also be considered as alternatives, offering similar anti-inflammatory effects but with potentially different pharmacokinetic properties. These alternatives may offer advantages in terms of potency, bioavailability, or side-effect profile.

What is the market or research trend for Beclomethasone (CAS: 4419-39-0)?

The market for Beclomethasone (CAS: 4419-39-0) continues to grow due to its wide application in asthma and other inflammatory diseases. Recent research trends focus on developing more potent and less immunosuppressive derivatives. Market analysis indicates increasing demand for innovative formulations and improved delivery systems. Additionally, there is growing interest in understanding the long-term effects and optimizing therapeutic regimens to reduce side effects.

How should waste containing Beclomethasone (CAS: 4419-39-0) be handled?

Waste containing Beclomethasone (CAS: 4419-39-0) should be handled with care to prevent environmental contamination. Collect waste liquids in appropriate containers and store them under controlled conditions to avoid degradation. Incineration is the preferred method for disposal, and professional waste disposal services should be utilized. Ensure all waste is properly labeled and that all safety precautions are followed to protect the environment and human health. Compliance with local regulations is essential to ensure proper disposal and handling.