Eribulin Mesylate

Basic Information

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CAS Number

441045-17-6

Molecular Formula

C41H63NO14S

Molecular Weight

826.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC1CC2CCC3C(=C)CC(O3)CCC45CC6C(O4)C7C(O6)C(O5)C8C(O7)CCC(O8)CC(=O)CC9C(CC(C1=C)O2)OC(C9OC)CC(CN)O.CS(=O)(=O)O

InChI

InChI=1S/C40H59NO11.CH4O3S/c1-19-11-24-5-7-28-20(2)12-26(45-28)9-10-40-17-33-36(51-40)37-38(50-33)39(52-40)35-29(49-37)8-6-25(47-35)13-22(42)14-27-31(16-30(46-24)21(19)3)48-32(34(27)44-4)15-23(43)18-41;1-5(2,3)4/h19,23-39,43H,2-3,5-18,41H2,1,4H3;1H3,(H,2,3,4)/t19-,23+,24+,25-,26+,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39+,40+;/m1./s1

InChIKey

QAMYWGZHLCQOOJ-WRNBYXCMSA-N

LogP

2.9420000000000046

Topological Polar Surface Area

200.76 Å²

Hydrogen Bond Donor/Acceptor

4 / 15

Complexity

1470

Synonyms & References

English

Eribulin Mesilate
E7389
11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-I]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-,2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-,methanesulfonate (salt)
Eribulin Mesylate
B1939 mesylate
E7389 mesylate
ER-086526 mesylate
Halaven
Eribulin (mesylate)
Eribulin mesylate
2-[(2S)-3-amino-2-hydroxypropyl] hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-(2R,3R
3aS
7R
8aS
9S
10aR
11S
12R,13aR
13bS
15S
18S
21S
24S
26R
28R
29aS)-11,15:18,21:24
28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i] furo[2’,3’:5
6]pyrano[4,3-b][1,4]dioxacyclopent acosin-5(4H)-one
methanesulfonate (1:1)
EX-A4873
ERIBULIN MESYLATE [ORANGE BOOK]

MDL Number

MFCD22572760

FAQ

What is Eribulin Mesylate (CAS: 441045-17-6)?

Eribulin Mesylate is a semi-synthetic analog of dolastatin 10, a naturally occurring compound with potent anti-cancer properties. It is used in the treatment of metastatic breast cancer and peripheral T-cell lymphoma. The compound has a molecular formula of C33H41N3O7S and belongs to the class of macrolides.

What are the main uses of Eribulin Mesylate (CAS: 441045-17-6)?

Eribulin Mesylate is primarily used as an antineoplastic agent in the treatment of metastatic breast cancer and peripheral T-cell lymphoma. It works by inhibiting microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells.

Is Eribulin Mesylate (CAS: 441045-17-6) safe?

Eribulin Mesylate is generally considered safe when used under medical supervision. However, it can cause side effects such as peripheral neuropathy, fatigue, and nausea. Patients should follow medical advice and take necessary precautions to avoid adverse reactions.

How should Eribulin Mesylate (CAS: 441045-17-6) be stored?

Eribulin Mesylate should be stored in a tightly sealed container at 15°C to 30°C (59°F to 86°F). It should be protected from light and kept away from heat sources. The drug should be handled with care to avoid exposure to skin or mucous membranes.