4-(Aminomethyl)aniline

Basic Information

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CAS Number

4403-71-8

Molecular Formula

C7H10N2

Molecular Weight

122.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Melting Point

37 °C

Boiling Point

101 °C/0.05 mmHg

Refractive Index

n20/D 1.61(lit.)

SMILES

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C1=CC(=CC=C1CN)N

InChI

InChI=1S/C7H10N2/c8-5-6-1-3-7(9)4-2-6/h1-4H,5,8-9H2

InChIKey

BFWYZZPDZZGSLJ-UHFFFAOYSA-N

LogP

0.7275

Topological Polar Surface Area

52.04 Å²

Hydrogen Bond Donor/Acceptor

4 / 2

Complexity

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Synonyms & References

English

SCHEMBL76433
AB6065
BDBM50408786
PS-3520
4403-71-8
4-Aminobenzylamine, 99%
SCHEMBL7190155
FT-0617567
STR08584
4-aminomethylphenylamine
DTXSID30330206
4-aminobenzenemethanamine
Q27455357
Benzenemethanamine, 4-amino-
AKOS003264923
CHEMBL148476
4-Amonobenzylae
4-aminomethyl-aniline
4-amino benzylamine
MFCD00075513
BFWYZZPDZZGSLJ-UHFFFAOYSA-N
4-Aminobenzylamine
EN300-79056
4-(AMINOMETHYL)BENZENAMINE
p-Aminobenzylamin
4-amino-benzylamine
InChI=1/C7H10N2/c8-5-6-1-3-7(9)4-2-6/h1-4H,5,8-9H
[4-(aminomethyl)phenyl]amine
A25056
N-(4-aminophenylmethyl)amine
p-Aminobenzylamine;Benzenemethanamine, 4-amino-

MDL Number

MFCD00075513

Customs Code

2921590090

FAQ

What are the physical and chemical properties of 4-(Aminomethyl)aniline (CAS: 4403-71-8)?

4-(Aminomethyl)aniline (CAS: 4403-71-8) is a white crystalline solid at room temperature, with a molecular weight of approximately 121.14 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is highly reactive due to the presence of a primary amine and an aromatic ring, making it susceptible to nucleophilic substitution and electrophilic aromatic substitution reactions.

How is 4-(Aminomethyl)aniline (CAS: 4403-71-8) typically synthesized?

4-(Aminomethyl)aniline (CAS: 4403-71-8) is commonly synthesized via the reduction of 4-chloromethylbenzene using sodium borohydride in aqueous media. The reaction is selective with a good yield, and the process involves a one-step reduction followed by workup and purification steps to isolate the desired product.

What industries use 4-(Aminomethyl)aniline (CAS: 4403-71-8)?

4-(Aminomethyl)aniline (CAS: 4403-71-8) is primarily used in the pharmaceutical industry for the synthesis of various drugs and intermediates. It is also utilized in the production of dyes and pigments, as well as in the development of sensors and semiconductors.

What precautions should be taken when handling 4-(Aminomethyl)aniline (CAS: 4403-71-8)?

Handling 4-(Aminomethyl)aniline (CAS: 4403-71-8) requires strict safety measures. It should be stored in a cool, dry place away from direct sunlight and heat sources. Use appropriate personal protective equipment (PPE), such as gloves and eye protection. Work in a well-ventilated area or fume hood to prevent inhalation. In case of a spill, use appropriate containment and follow safety data sheet (SDS) guidelines for disposal.