N-(3-Thienyl)acetamide

Basic Information

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CAS Number

42602-67-5

Molecular Formula

C6H7NOS

Molecular Weight

141.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Boiling Point

325.0±15.0°C at 760 mmHg

Density

1.26

Flash Point

150.3℃

Refractive Index

1.611

SMILES

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CC(=O)NC1=CSC=C1

InChI

InChI=1S/C6H7NOS/c1-5(8)7-6-2-3-9-4-6/h2-4H,1H3,(H,7,8)

InChIKey

QHXQVXGAEYDJCR-UHFFFAOYSA-N

LogP

1.7065

Topological Polar Surface Area

29.1 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

116

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

SCHEMBL4131287
DS-17505
42602-67-5
A872851
DTXSID80195367
THIOPHENE, 3-ACETAMIDO-
AT99M83XCR
N-thiophen-3-ylacetamide
3-acetamidothiophene
SY002880
Acetamide, N-3-thienyl-
AB04169
NSC 115029
UNII-AT99M83XCR
CS-0153960
N-(3-THIENYL)ACETAMIDE
AKOS000281670
EN300-77162
N-(thiophen-3-yl)acetamide
3-(ACETYLAMINO)THIOPHENE
FT-0724064
QHXQVXGAEYDJCR-UHFFFAOYSA-N
EINECS 255-907-6
AMY2018
NSC-115029
MFCD00159570
NS00031220
N-3-Thienylacetamide
NSC115029
N-(Thiophen-3-yl)acetamide
N-(3-Thienyl)acetamide

MDL Number

MFCD00159570

FAQ

What are the physical and chemical properties of N-(3-Thienyl)acetamide (CAS: 42602-67-5)?

N-(3-Thienyl)acetamide (CAS: 42602-67-5) is a solid with a crystalline form. It has a molecular weight of approximately 145.19 g/mol. The compound is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. It reacts readily with bases to form the corresponding amine and acetate salt. It is stable under normal conditions but should be stored away from strong acids and oxidizing agents.

How is N-(3-Thienyl)acetamide (CAS: 42602-67-5) typically synthesized?

N-(3-Thienyl)acetamide is typically synthesized by reacting thioacetamide with 3-bromothiophene in the presence of a base like sodium hydride. The reaction yields high selectivity and good yield, with the product isolated by recrystallization from water or an organic solvent. This method is widely used in academic and industrial settings for the preparation of this compound.

What industries use N-(3-Thienyl)acetamide (CAS: 42602-67-5)?

N-(3-Thienyl)acetamide (CAS: 42602-67-5) finds applications in various industries due to its chemical properties. It is used in the pharmaceutical industry for synthesizing certain drugs due to its thienyl group. Additionally, it is used in polymer synthesis, sensors, and semiconductor applications for its thiophene group, which contributes to its electronic and structural properties.

What precautions should be taken when handling N-(3-Thienyl)acetamide (CAS: 42602-67-5)?

When handling N-(3-Thienyl)acetamide (CAS: 42602-67-5), safety is paramount. Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a fume hood to minimize exposure. If a spill occurs, neutralize the spill with a suitable absorbent material and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling guidelines and emergency procedures.