Fenofibrate EP Impurity A (Fenofibrate USP Related Compound A)

Basic Information

View in Editor

CAS Number

42019-78-3

Molecular Formula

C13H9ClO2

Molecular Weight

232.67 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

175-178 °C

Boiling Point

257 °C/13 mmHg

Flash Point

100 ºC

Refractive Index

1.5434 (estimate)

SMILES

View in Editor

C1=CC(=CC=C1C(=O)C2=CC=C(C=C2)Cl)O

InChI

InChI=1S/C13H9ClO2/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8,15H

InChIKey

RUETVLNXAGWCDS-UHFFFAOYSA-N

LogP

3.276600000000001

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

238

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

REGID_for_CID_123504
(4-Chlorophenyl)(4-hydroxyphenyl)methanone
4-chlorophenyl 4-hydroxyphenyl ketone
FT-0618103
Z104495480
UNII-FF9YB926A3
4-chloro-4'-hydroxy-benzophenone
4-CHLORO-4-HYDROXYBENZOPHENONE
CHEMBL1438628
BCP24465
PD055587
W-106286
42019-78-3
EC 255-627-4
AC-7312
NCGC00258527-01
A18763
SMR000054541
CAS-42019-78-3
MFCD00002357
Tox21_200974
(4-Chlorophenyl)(4-hydroxyphenyl)methanone #
BENZOPHENONE, 4-CHLORO-4'-HYDROXY- (6CI)
AKOS000120539
EN300-21344
4-Chloro-4 inverted exclamation mark -hydroxybenzophenone
Fenofibrate impurity A, European Pharmacopoeia (EP) Reference Standard
MLS000104608
DTXSID4047961
4-(4-chlorobenzoyl)-phenol
4-Chloro-4`-hydroxybenzophenone

MDL Number

MFCD00002357

Customs Code

2914700090

FAQ

What is Fenofibrate EP Impurity A (CAS: 42019-78-3)?

Fenofibrate EP Impurity A (CAS: 42019-78-3) is a chemical compound identified as a specific impurity in the pharmaceutical drug Fenofibrate. It has the molecular formula C18H22O4 and is characterized by its structural similarity to Fenofibrate, with minor variations in functional groups. This compound is commonly encountered during the synthesis and purification of Fenofibrate, requiring precise analytical methods for detection and quantification in drug quality control processes.

What are the main uses of Fenofibrate EP Impurity A (CAS: 42019-78-3)?

Fenofibrate EP Impurity A (CAS: 42019-78-3) is primarily used in pharmaceutical research to identify and analyze impurities in Fenofibrate preparations. It plays a critical role in ensuring drug purity and compliance with regulatory standards like USP and EP. Additionally, it is employed in the development of analytical methods for quality assurance and in studying the stability and degradation pathways of Fenofibrate in pharmaceutical formulations.

Is Fenofibrate EP Impurity A (CAS: 42019-78-3) safe?

Fenofibrate EP Impurity A (CAS: 42019-78-3) is generally considered safe when handled properly in controlled environments. However, as a chemical impurity, it may pose risks if exposed in high concentrations, such as potential irritation to skin or eyes. Safety protocols include wearing personal protective equipment (PPE) and following standard laboratory practices. Regulatory guidelines emphasize its safe use in pharmaceutical testing and research settings.

How should Fenofibrate EP Impurity A (CAS: 42019-78-3) be stored?

Fenofibrate EP Impurity A (CAS: 42019-78-3) should be stored in a cool, dry place, away from direct light and moisture. It is typically kept in airtight containers to maintain stability and prevent contamination. Proper storage conditions ensure its chemical integrity and adherence to pharmaceutical standards, minimizing degradation risks during handling and experimentation.