4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide | CAS No. 417716-92-8

4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide

Basic Information

CAS Number

417716-92-8

Molecular Formula

C21H19ClN4O4

Molecular Weight

426.86 g/mol

AD

Basic Physical Properties

Boiling Point

627.2°C at 760 mmHg

COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(=O)N

InChI

InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)

InChIKey

WOSKHXYHFSIKNG-UHFFFAOYSA-N

LogP

4.071900000000002

Topological Polar Surface Area

115.57000000000001 Ų

Hydrogen Bond Donor/Acceptor

4 / 8

Complexity

634

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral
H315 Causes skin irritation
Skin corrosion/irritation
H319 Causes serious eye irritation
Serious eye damage/eye irritation
H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

  • 4-[3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide
  • lenvatinib
  • Lenvatinib (E7080)
  • 4-(3-Chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide
  • 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide
  • E7080
  • E7080 (Lenvatinib)
  • Lenvatinib E7080
  • E-7080
  • E7080,E 7080
  • Lenvima
  • E 7080
  • 4-{3-Chloro-4-[(Cyclopropylcarbamoyl)amino]phenoxy}-7-Methoxyquinoline-6-Carboxamide
  • EE083865G2
  • AK175809
  • Lenv
  • Lenvatinib
  • 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide

MDL Number

MFCD16038644

FAQ

What is 4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide (CAS: 417716-92-8)?

4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide (CAS: 417716-92-8) is a synthetic organic compound with a complex structure containing a quinoline ring system. It is characterized by the presence of a methoxy group, a chloro substituent, and a cyclopropylcarbamoyl amino group. This compound is known for its potential biological activity and is often studied in pharmaceutical research.

What are the main uses of 4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide (CAS: 417716-92-8)?

This compound is primarily used in pharmaceutical research for its potential as a therapeutic agent. It may be explored for applications in treating diseases such as cancer or infections due to its structural features that suggest biological activity. It is also used in chemical synthesis and as a building block for drug development.

Is 4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide (CAS: 417716-92-8) safe?

The safety of 4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide (CAS: 417716-92-8) depends on its application. In research settings, it should be handled with appropriate precautions, including the use of personal protective equipment. Its toxicity profile is not well-documented, so standard safety protocols for chemical handling are recommended.

How should 4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide (CAS: 417716-92-8) be stored?

4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide (CAS: 417716-92-8) should be stored in a cool, dry, and dark place, away from moisture and light. It is typically kept in a sealed container at a temperature below 25°C to maintain stability and prevent degradation.

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