3-Thiophenecarbonyl chloride

Basic Information

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CAS Number

41507-35-1

Molecular Formula

C5H3ClOS

Molecular Weight

146.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

51-54 °C

Boiling Point

195.4°C at 760 mmHg

Density

1.391

Refractive Index

1.576

SMILES

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C1=CSC=C1C(=O)Cl

InChI

InChI=1S/C5H3ClOS/c6-5(7)4-1-2-8-3-4/h1-3H

InChIKey

QTWBEVAYYDZLQL-UHFFFAOYSA-N

LogP

2.1271000000000004

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

105

Safety Information

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Hazard Statement

H228 Flammable solid
Flammable solids

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

3-Thenoyl chloride
AT17064
F2190-0160
EINECS 255-420-9
A825573
QTWBEVAYYDZLQL-UHFFFAOYSA-N
SCHEMBL642102
3-Thiophenecarboxylic acid chloride
thiophene-3-carbonyl chloride
3-thienylcarbonyl chloride
MFCD00130090
3-thiophene carbonyl chloride
BP-10038
41507-35-1
3-Thiophenzoyl Chloride
EPT4LKL45Z
HYDROCOTARNINEHYDROBROMIDE
J-513114
3-CHLOROCARBONYLTHIOPHENE
NS00056858
EN300-212163
FT-0616407
thiophene-3-carboxylic acid chloride
AKOS000281429
Thiophene-3-carbonyl chloride, 97%
3-Thiophenecarbonyl chloride
3-Thiophenecarbonylchloride
CS-10914
AMY28736
DTXSID40194391
3-thiophenecarboxylic acid chloride

MDL Number

MFCD00130090

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 3-Thiophenecarbonyl chloride (CAS: 41507-35-1)?

3-Thiophenecarbonyl chloride is a white crystalline solid with a molecular weight of approximately 153.16 g/mol. It has a low solubility in water but is more soluble in organic solvents like acetone and chloroform. It is highly reactive, forming adducts with nucleophiles and undergoes nucleophilic substitution reactions. It is commonly used as a coupling reagent in organic synthesis.

How is 3-Thiophenecarbonyl chloride (CAS: 41507-35-1) typically synthesized?

3-Thiophenecarbonyl chloride is typically synthesized by the chlorination of 3-thiophenecarboxylic acid. This involves the reaction of 3-thiophenecarboxylic acid with phosphorus trichloride or thionyl chloride under appropriate conditions to yield the desired product. The reaction is carried out with careful control to ensure high yield and selectivity.

What industries use 3-Thiophenecarbonyl chloride (CAS: 41507-35-1)?

3-Thiophenecarbonyl chloride is widely used in the pharmaceutical, polymer, and sensor industries. It serves as a key intermediate in the synthesis of various drugs, polymers, and sensing materials due to its reactivity and functionality. Additionally, it is used in the semiconductor industry for the preparation of functionalized thiophene derivatives.

What precautions should be taken when handling 3-Thiophenecarbonyl chloride (CAS: 41507-35-1)?

When handling 3-Thiophenecarbonyl chloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Refer to the Safety Data Sheet (SDS) for specific safety guidelines and emergency procedures.