Belinostat(PXD-101)

Basic Information

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CAS Number

414864-00-9

Molecular Formula

C15H14N2O4S

Molecular Weight

318.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Density

1.427

Refractive Index

1.667

SMILES

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C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO

InChI

InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

InChIKey

NCNRHFGMJRPRSK-MDZDMXLPSA-N

LogP

2.006

Topological Polar Surface Area

95.5 Å²

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

492

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

BELINOSTAT [VANDF]
L01XX49
BCP9000386
CHEMBL408513
A25012
DTXSID60194378
NSC-758774
B5888
Belinostat [USAN:INN]
NSC758774
Belinostat
AKOS025401741
NCGC00263155-02
CHEBI:61076
(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
(E)-3-[3-(phenylsulfamoyl)phenyl]prop-2-enehydroxamic acid
N-HYDROXY-3-(3-PHENYLSULFAMOYLPHENYL)ACRYLAMIDE
MLS006011091
(E)-N-hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide
Belinostat (USAN/INN)
PX105684
BCP01741
(2E)-N-HYDROXY-3-(3-(PHENYLSULFAMOYL)PHENYL)PROP-2-ENAMIDE
Belinostat,PXD101, PX105684
F4H96P17NZ
belinostatum
GTPL7496
BELINOSTAT [INN]
Beleodaq (TN)
NS00069313
SW219445-1

MDL Number

MFCD08064035

Customs Code

2935009090

FAQ

What regulatory guidelines apply to Belinostat (CAS: 414864-00-9)?

Belinostat (CAS: 414864-00-9) falls under the regulatory guidelines of the Chemicals in the European Union (REACH) and the U.S. Food and Drug Administration (FDA). It is classified under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) as a substance that may cause skin irritation and sensitization. Specific testing and documentation requirements for handling, storage, and transportation are mandated under REACH and OSHA (Occupational Safety and Health Administration) guidelines.

Are there alternatives to Belinostat (CAS: 414864-00-9) in synthesis?

There are several alternatives to Belinostat (CAS: 414864-00-9) in synthesis, such as other histone deacetylase inhibitors (HDACi) likeentinostat and mocetinostat. These compounds can serve as viable alternatives depending on the specific requirements of the synthesis process. Additionally, researchers often explore use of common reagents like sodium acetate and ethanol in the synthesis of related compounds.

What is the market or research trend for Belinostat (CAS: 414864-00-9)?

The market and research trend for Belinostat (CAS: 414864-00-9) is focused on its use as an antineoplastic agent, particularly in the treatment of hematologic malignancies and solid tumors. Recent trends indicate a growing interest in its combination therapies and the exploration of its mechanism of action. Research is also expanding into the development of more potent and selective HDAC inhibitors to improve efficacy and reduce side effects.

How should waste containing Belinostat (CAS: 414864-00-9) be handled?

Waste containing Belinostat (CAS: 414864-00-9) should be collected in properly labeled, sealed containers and stored in a safe, secure area. Disposal should be handled by a certified hazardous waste management company. Incineration is a common method, but other professional waste disposal services may be required depending on local regulations. Environmental precautions include ensuring that no waste is released into the environment and that all handlers follow safety protocols to prevent exposure.