Potassium bis(trimethylsilyl)amide

Basic Information

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CAS Number

40949-94-8

Molecular Formula

C6H18KNSi2

Molecular Weight

199.48 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Hydrocarbons

Basic Physical Properties

Melting Point

No data available

Boiling Point

111 °C

Water Solubility

Reacts with water.

Solubility

Miscible with terahydrofuran, ether, benzene and toluene.

Refractive Index

1.4920

Vapor Pressure

54 mmHg ( 25 °C)

SMILES

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C[Si](C)(C)[N-][Si](C)(C)C.[K+]

InChI

InChI=1S/C6H18NSi2.K/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1

InChIKey

IUBQJLUDMLPAGT-UHFFFAOYSA-N

LogP

2.42250

Complexity

80.9

Safety Information

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GHS Hazard Pictograms

H225

H304

H314

H336

H373

Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H304 May be fatal if swallowed and enters airways
Aspiration hazard

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

H336 May cause drowsiness or dizziness
Specific target organ toxicity, single exposure; Narcotic effects

H373 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Hazard Class

Class 3 Class 3

Sensitiveness

Moisture Sensitive

Synonyms & References

English

Hexamethyldisilazane potassium salt
BP-21018
potassium 1,1,1,3,3,3-hexamethyl-disilazane
BP-12745
Potassium Bis(trimethylsilyl)azanide
Potassium Hexamethyldisilazide
potassium hexamethyldisilazanide
SCHEMBL2038
H0893
IUBQJLUDMLPAGT-UHFFFAOYSA-N
potassium bis(trimethylsily)amide
Q903636
potassium N,N-bis(trimethylsilyl)amide
potassium bis-(trimethylsilyl)-amide
potassium bis(trimethylsilyl)-amide
potassium bis-(trimethylsilyl)amide
Potassium bis(trimethylsilyl)amide, 15 wt. % in toluene
3-(5-(Pyridin-4-ylmethyl)-5H-cyclopenta[1,2-b:5,4-b']dipyridin-5-yl)cyclohexanone
KHMDS
Potassium hexamethyldisilyl azide
Potassium Bis(trimethylsilyl)amide (95%)
DTXSID00390655
P2730
potassium bis (trimethylsilyl)amide
Potassium Bis(trimethylsilyl)amide (14% in Toluene, ca. 0.6mol/L)
Potassium bis(trimethylsilyl)amide, 95%
potassium bis-trimethylsilylamide
potasium hexamethyldisilazide
potassium bis(trimethylsilyl) amide
Potassium bis(trimethylsilyl)amide
40949-94-8

MDL Number

MFCD00010330

Customs Code

2931900090

FAQ

What regulatory guidelines apply to Potassium bis(trimethylsilyl)amide (CAS: 40949-94-8)?

Potassium bis(trimethylsilyl)amide (CAS: 40949-94-8) is regulated under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) for its potential hazards, including flammability and skin/eye irritation. In the European Union, it falls under the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation. Additionally, the Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) have specific guidelines for its use in pharmaceutical and industrial applications, focusing on safety and environmental impact.

Are there alternatives to Potassium bis(trimethylsilyl)amide (CAS: 40949-94-8) in synthesis?

While Potassium bis(trimethylsilyl)amide (CAS: 40949-94-8) is a valuable reagent, alternatives such as other silylating agents like tert-butyldimethylsilyl chloride or tert-butyldimethylsilyl trifluoroacetate can be used in synthesis. These alternatives offer similar functionality but with different reactivity and utility in various chemical transformations.

What is the market or research trend for Potassium bis(trimethylsilyl)amide (CAS: 40949-94-8)?

The market for Potassium bis(trimethylsilyl)amide (CAS: 40949-94-8) is driven by its use in organic synthesis, particularly in the pharmaceutical and polymer industries. Current research trends focus on its applications in catalysis and as a protecting group in organic reactions. Market trends indicate increasing demand, especially due to its role in green chemistry initiatives and its ability to enhance the efficiency of chemical processes.

How should waste containing Potassium bis(trimethylsilyl)amide (CAS: 40949-94-8) be handled?

Waste containing Potassium bis(trimethylsilyl)amide (CAS: 40949-94-8) should be collected in a sealed container and disposed of through a professional hazardous waste disposal service. Incineration is a common method for waste disposal, provided it is done in an enclosed, controlled environment to minimize environmental impact. Proper handling includes ensuring no leakage and adherence to local environmental protection regulations to prevent contamination of soil and water sources.