2-Bromo-6-methoxypyridine

Basic Information

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CAS Number

40473-07-2

Molecular Formula

C6H6BrNO

Molecular Weight

188.02 g/mol

EINECS

628-883-3

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Clear colorless to golden

Melting Point

No data available

Boiling Point

206 °C

Density

1.53 g/mL at 25 °C

Flash Point

220 °F

Refractive Index

n20/D 1.559(lit.)

Vapor Pressure

No data available

SMILES

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COC1=NC(=CC=C1)Br

InChI

InChI=1S/C6H6BrNO/c1-9-6-4-2-3-5(7)8-6/h2-4H,1H3

InChIKey

KMODISUYWZPVGV-UHFFFAOYSA-N

LogP

1.8527

pKa

-1.04±0.10(Predicted)

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

89.1

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

KMODISUYWZPVGV-UHFFFAOYSA-N
J-400275
2-bromo-6-methoxy pyridine
SCHEMBL6964
2-Bromo-6-(methyloxy)pyridine
Pyridine, 2-bromo-6-methoxy-
CS-D1443
MFCD00088345
FG-0479
FT-0645299
NSC 84173
F1967-3368
2-Bromo-6-methoxypyridine
40473-07-2
6-bromo-2-methoxypyridine
NSC-84173
NSC84173
2-Bromo-6-methoxypyridine, 97%
2-Bromo-6-methoxy-pyridine
B3260
DTXSID90292619
AKOS005259640
2-bromo-6-methoxy-pyridin
AM20070028
AC-4757
SY007898
BCP27534
EN300-87222
2-Bromo-6-methoxypyridine ,98%
2-Bromo-6-methoxy-pyridine ,97%
2-Bromo-6-methoxypyrimidine ,98%

MDL Number

MFCD00088345

EC Number

628-883-3

Customs Code

29333990

FAQ

What are the physical and chemical properties of 2-Bromo-6-methoxypyridine (CAS: 40473-07-2)?

2-Bromo-6-methoxypyridine is a crystalline compound with a molecular weight of approximately 225.03 g/mol. It has a low solubility in water (less than 1 g/L) but is more soluble in organic solvents such as ethanol and acetone. The compound is moderately reactive, particularly towards nucleophiles and bases. It can form complexes with transition metals and exhibits spectral properties suitable for spectroscopic studies.

How is 2-Bromo-6-methoxypyridine (CAS: 40473-07-2) typically synthesized?

2-Bromo-6-methoxypyridine is commonly synthesized through the bromination of 6-methoxypyridine using bromine and a Lewis acid catalyst, such as aluminum bromide. The reaction typically provides a yield of around 70-80% under standard conditions. The process involves the electrophilic bromination of the pyridine ring, followed by quenching with a base to obtain the final product.

What industries use 2-Bromo-6-methoxypyridine (CAS: 40473-07-2)?

2-Bromo-6-methoxypyridine finds applications in the pharmaceutical industry for the synthesis of certain drug candidates. It is also utilized in the chemical industry for the development of new materials, particularly in the preparation of functional polymers and sensors. The compound may also play a role in the semiconductor industry due to its electronic properties.

What precautions should be taken when handling 2-Bromo-6-methoxypyridine (CAS: 40473-07-2)?

When handling 2-Bromo-6-methoxypyridine, it is essential to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. In the event of a spill, it is recommended to use absorbent materials and dispose of them according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.