Amikacin disulfate

Basic Information

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CAS Number

39831-55-5

Molecular Formula

C22H47N5O21S2

Molecular Weight

781.8 g/mol

EINECS

254-648-6

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

white to off-white

Melting Point

220-230 C

Boiling Point

No data available

Density

No data available

Water Solubility

Soluble in water at 50mg/ml with warming

Flash Point

No data available

Solubility

H2O: 50 mg/mL, clear, colorless

Vapor Pressure

No data available

Specific Rotation

D22 +74.75° (water)

SMILES

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C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O

InChI

InChI=1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1

InChIKey

FXKSEJFHKVNEFI-GCZBSULCSA-N

LogP

-9.729800000000017

Topological Polar Surface Area

481.14000000000004 Å²

Hydrogen Bond Donor/Acceptor

21 / 26

Complexity

900

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 oral in rabbit: > 3gm/kg

Synonyms & References

English

Amikacin (sulfate)
Amikacin sulfate [USAN:USP:JAN]
MFCD00167475
EINECS 254-648-6
AMIKACIN SULFATE [EP IMPURITY]
AMIKACIN SULFATE [USP MONOGRAPH]
Amikan
AMIKACIN SULFATE
AMIKACIN SULFATE [WHO-DD]
AMIKACIN SULFATE [ORANGE BOOK]
Amikacin sulphate
CHEMBL4208954
AMIKACINI SULFAS [WHO-IP]
(S)-4-amino-N-((1R,2S,3S,4R,5S)-5-amino-2-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4-(((2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide bis(sulfate)
D00865
D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4))-N(SUP 1)-(4-AMINO-2-HYDROXY-1-OXOBUTYL)-2-DEOXY-, (S)-, SULPHATE (1:2) (SALT)
(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide disulfate
Arikayce
Amikacin disulfate salt, potency: 674-786 mug per mg (as amikacin base)
NSC 755846
Amitrex
AMIKACIN SULFATE [MI]
NN-K 8
AMIKACIN SULFATE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER
AMIKACIN SULFATE [JAN]
HY-B0509B
Amikacin sulfate (JP17/USP)
Amikacin (disulfate)
Amikacini sulfas
D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-N(sup 1)-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, sulfate (1:2)(salt)
CCG-270466