(4-Fluorophenyl)(hydroxy)acetic acid

Basic Information

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CAS Number

395-33-5

Molecular Formula

C8H7FO3

Molecular Weight

170.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

135.0 to 139.0 deg-C

Flash Point

148.8℃

SMILES

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C1=CC(=CC=C1C(C(=O)O)O)F

InChI

InChI=1S/C8H7FO3/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,7,10H,(H,11,12)

InChIKey

RWCMOQXHIDWDDJ-UHFFFAOYSA-N

LogP

0.9437

Topological Polar Surface Area

57.53 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

164

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

HMS1741H08
EN300-14674
4-fluoro mandelic acid
AC-431
(4-Fluorophenyl)(hydroxy)acetic acid #
SCHEMBL196919
(4-Fluorophenyl)(hydroxy)acetic acid
SY330232
NS00043189
MFCD20643876
AKOS016051387
Benzeneacetic acid, 4-fluoro-.alpha.-hydroxy-
A824605
p-fluoromandelic acid
CCA92325
AKOS001138736
PS-6578
NCI60_041621
4-Fluoro-DL-mandelic Acid
4-Fluoro(hydroxy)acetic acid
2-(4-fluorophenyl)-2-hydroxyacetic acid
NCGC00337099-01
395-33-5
4-Fluoromandelicacid
CS-0059151
4-Fluoromandelic acid
DTXSID701314910
EINECS 206-899-8
NSC73990
FT-0618540
H10731

MDL Number

MFCD00044402

Customs Code

2918199090

FAQ

What are the physical and chemical properties of (4-Fluorophenyl)(hydroxy)acetic acid (CAS: 395-33-5)?

(4-Fluorophenyl)(hydroxy)acetic acid is a white crystalline solid with a molecular weight of approximately 194.13 g/mol. It has a melting point of around 196-198°C and a high solubility in water. This compound is moderately reactive, showing reactivity towards bases and some organic reagents. It is used in various applications requiring its specific reactivity and solubility properties.

How is (4-Fluorophenyl)(hydroxy)acetic acid (CAS: 395-33-5) typically synthesized?

(4-Fluorophenyl)(hydroxy)acetic acid can be synthesized by the condensation of 4-fluorophenol with acetic anhydride, followed by hydrolysis. Commonly, this reaction is catalyzed by a strong acid like sulfuric acid, providing good yield and selectivity. The reaction conditions and purity of starting materials are crucial for achieving high-quality products.

What industries use (4-Fluorophenyl)(hydroxy)acetic acid (CAS: 395-33-5)?

(4-Fluorophenyl)(hydroxy)acetic acid finds applications in pharmaceuticals, where its unique structural features can be utilized for drug development. It is also used in the synthesis of certain polymers for their enhanced properties. Additionally, it plays a role in the production of sensors and semiconductors, benefiting from its specific reactivity and solubility characteristics.

What precautions should be taken when handling (4-Fluorophenyl)(hydroxy)acetic acid (CAS: 395-33-5)?

Proper handling of (4-Fluorophenyl)(hydroxy)acetic acid requires the use of appropriate personal protective equipment (PPE), such as gloves and safety goggles. It should be stored in a cool, dry place, away from incompatible materials. Handling should be performed in a well-ventilated area or fume hood. In case of spill, avoid inhalation of dust and wash the area thoroughly. Always refer to the Safety Data Sheet (SDS) for detailed safety information.