2-Fluorobenzoyl chloride

Basic Information

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CAS Number

393-52-2

Molecular Formula

C7H4ClFO

Molecular Weight

158.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

4 °C

Boiling Point

90-92 °C/15 mmHg

Refractive Index

n20/D 1.536(lit.)

SMILES

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C1=CC=C(C(=C1)C(=O)Cl)F

InChI

InChI=1S/C7H4ClFO/c8-7(10)5-3-1-2-4-6(5)9/h1-4H

InChIKey

RAAGZOYMEQDCTD-UHFFFAOYSA-N

LogP

2.2047

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

138

Safety Information

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GHS Hazard Pictograms

H314

H335

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Lachrymatory

Synonyms & References

English

2-fluorobenzoylchloride
alpha-chloro-2-fluorobenzaldehyde
Benzoyl chloride, 2-fluoro-
2-FLUOROBENZOYL CHLORIDE
2-Fluorobenzoyl chloride, 99%
AKOS000121330
2-fluoro benzoic acid chloride
D70825
FT-0612419
DTXCID005330
Benzoyl chloride, o-fluoro-
NCGC00091418-01
CAS-393-52-2
Q27294989
DTXSID3025330
SCHEMBL60101
NCGC00258191-01
BRN 0636864
F0195
2-fluoro-1-benzenecarbonyl chloride
NCGC00091418-02
2-fluoro-benzoylchloride
NSC 88304
EC 206-887-2
UNII-Z4H017N76S
PB42721
F2190-0058
NSC88304
fluorobenzoyl chloride
o-Fluorobenzoyl chloride
MFCD00000656

MDL Number

MFCD00000656

Customs Code

29163900

FAQ

What is 2-Fluorobenzoyl chloride (CAS: 393-52-2)?

2-Fluorobenzoyl chloride (CAS: 393-52-2) is a fluorinated aromatic compound with the chemical formula C7H5ClFO2. It is a colorless liquid with a strong, pungent odor, known for its reactivity and utility in organic synthesis. The molecule features a benzene ring substituted with a fluorine atom at the 2-position and a chlorine atom attached to the carbonyl group, making it a key intermediate in various chemical processes.

What are the main uses of 2-Fluorobenzoyl chloride (CAS: 393-52-2)?

2-Fluorobenzoyl chloride (CAS: 393-52-2) is widely used in pharmaceuticals for synthesizing drugs with fluorinated aromatic moieties. It also serves as an industrial chemical in the production of dyes, pesticides, and other organic compounds. In research, it acts as a versatile reagent for creating fluorinated derivatives, particularly in medicinal chemistry and functional group transformations.

Is 2-Fluorobenzoyl chloride (CAS: 393-52-2) safe?

2-Fluorobenzoyl chloride (CAS: 393-52-2) is toxic and requires careful handling. It is corrosive to skin and eyes, and inhalation or ingestion can cause severe health effects. Safety precautions include using personal protective equipment (PPE), ensuring proper ventilation, and following OSHA and REACH guidelines. It is not considered safe for direct contact or without appropriate safety measures.

How should 2-Fluorobenzoyl chloride (CAS: 393-52-2) be stored?

2-Fluorobenzoyl chloride (CAS: 393-52-2) should be stored in a cool, dry, and dark place, ideally below 25°C. Keep it in a tightly sealed container made of glass or stainless steel to prevent exposure to moisture and air. Avoid high humidity and direct light to maintain stability. Ensure proper ventilation in storage areas to minimize risks associated with its volatile nature.