Pertuzumab | CAS No. 380610-27-5

Pertuzumab

Basic Information

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CAS Number

380610-27-5

Molecular Formula

C17H27NO2

Molecular Weight

277.41 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Physical Properties

SMILES

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CC(C)NC(C)C(O)COC1=CC=C(C)C2=C1CCC2

InChI

InChI=1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3

InChIKey

VFIDUCMKNJIJTO-UHFFFAOYSA-N

LogP

2.6099200000000007

Topological Polar Surface Area

41.489999999999995 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Synonyms & References

English

Pertuzumab
Pertuzumab [INN]; 2C4; Omnitarg; Omnitarg, 2C4; UNII-K16AIQ8CTM; rhuMAb 2C4; Immunoglobulin G1, anti-(human v (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer
pertuzumab
2C4
Immunoglobulin G1, anti-(human V (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer
Omnitarg
Unii-K16aiq8ctm
Pertuzumab (anti-HER2)
Pertuzumab-Perjeta
Research Grade Pertuzumab(DHC09602)

FAQ

What are the physical and chemical properties of Pertuzumab (CAS: 380610-27-5)?

Pertuzumab (CAS: 380610-27-5) is a glycoprotein therapeutic monoclonal antibody with a molecular weight of approximately 144 kDa. It is soluble in water and has a crystalline form that is stable under normal storage conditions. Pertuzumab is highly reactive with certain cell surface receptors, making it effective in inhibiting HER2 signaling pathways in cancer treatment.

How is Pertuzumab (CAS: 380610-27-5) typically synthesized?

Pertuzumab (CAS: 380610-27-5) is synthesized through recombinant DNA technology using mammalian cell cultures, such as Chinese hamster ovary (CHO) cells. The process involves gene cloning, cell transfection, and cell culture expansion. High yields and selectivity are achieved using optimized culture conditions and process controls.

What industries use Pertuzumab (CAS: 380610-27-5)?

Pertuzumab (CAS: 380610-27-5) is primarily used in the pharmaceutical industry for cancer treatment, specifically in combination with other therapies to target HER2-positive breast and gastric cancers. It is also utilized in the biotechnology sector for research and development of new cancer treatments.

What precautions should be taken when handling Pertuzumab (CAS: 380610-27-5)?

When handling Pertuzumab (CAS: 380610-27-5), laboratory personnel should use personal protective equipment (PPE) such as gloves, masks, and appropriate lab coats. It should be stored refrigerated at 2-8°C and protected from light. Spills should be handled with care according to safety data sheets (SDS) guidelines. Fume hoods should be used during administration to minimize inhalation risk.