(3-Bromo-1-propyn-1-yl)(trimethyl)silane | CAS No. 38002-45-8

Q: What are the physical and chemical properties of (3-Bromo-1-propyn-1-yl)(trimethyl)silane (CAS: 38002-45-8)?

(3-Bromo-1-propyn-1-yl)(trimethyl)silane is a colorless or light yellow liquid with a molecular weight of approximately 185.48 g/mol. It has a high boiling point and is slightly soluble in water but miscible with organic solvents. The compound is known for its reactivity, particularly towards nucleophiles and electrophiles, making it useful in organic synthesis. It can form stable complexes with various metal ions and exhibits significant spectroscopic reactivity.

Q: How is (3-Bromo-1-propyn-1-yl)(trimethyl)silane (CAS: 38002-45-8) typically synthesized?

(3-Bromo-1-propyn-1-yl)(trimethyl)silane is often synthesized using a Grignard reaction starting with 1-bromopropan-1-yl trimethylsilane and 1-propyn-1-ylium trimethylsilane. Commonly, the reaction is carried out in anhydrous ether with magnesium, producing the desired product with good yield. The reaction conditions include the use of a catalytic amount of titanium tetrachloride to improve selectivity and yield.

Q: What industries use (3-Bromo-1-propyn-1-yl)(trimethyl)silane (CAS: 38002-45-8)?

(3-Bromo-1-propyn-1-yl)(trimethyl)silane is primarily used in the pharmaceutical industry for the synthesis of various organic compounds. It also finds applications in polymer chemistry, where it can be used as a silicon source for functionalizing polymers. Additionally, it is utilized in the production of sensors and semiconductors, particularly in the modification of surfaces for improved electronic properties.

Q: What precautions should be taken when handling (3-Bromo-1-propyn-1-yl)(trimethyl)silane (CAS: 38002-45-8)?

When handling (3-Bromo-1-propyn-1-yl)(trimethyl)silane, it is essential to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. Ensure good ventilation in the laboratory by using a fume hood. Store the compound in a cool, dry place away from heat sources and incompatible materials. In case of a spill, immediately contain it and clean up using appropriate waste disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.

(3-Bromo-1-propyn-1-yl)(trimethyl)silane

Basic Information

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CAS Number

38002-45-8

Molecular Formula

C6H11BrSi

Molecular Weight

88.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Physical Properties

Melting Point

<0°C

Boiling Point

44-45 °C/2 mmHg

Water Solubility

Immiscible with water.

Refractive Index

n20/D 1.483(lit.)

SMILES

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C[Si](C)(C)C#CCBr

InChI

InChI=1S/C6H11BrSi/c1-8(2,3)6-4-5-7/h5H2,1-3H3

InChIKey

GAPRPFRDVCCCHR-UHFFFAOYSA-N

LogP

1.9544

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

120

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

sensitive to air and moisture

Synonyms & References

English

3-Bromo-1-(trimethylsilyl)-1-propyne, 98%
1-bromo-3-(trimethylsilyl)-2-propyne
InChI=1/C6H11BrSi/c1-8(2,3)6-4-5-7/h5H2,1-3H
3-(trimethylsilyl) propargyl bromide
MFCD00134460
s12035
AMY1270
(3-bromoprop-1-ynyl)trimethylsilane
DTXSID80349040
(3-Bromoprop-1-yn-1-yl)trimethylsilane
CS-W010730
EN300-92988
3-bromo-1-trimethylsilyl-1-propyne
AKOS015909351
A823959
silane, (3-bromo-1-propynyl)trimethyl-
GAPRPFRDVCCCHR-UHFFFAOYSA-N
3-Bromo-1-(Trimethylsilyl)-1-Propyne,95%
1-bromo-3-(trimethylsilyl)-2propyne
(3-bromo-prop-1-ynyl)-trimethyl-silane
3-Bromo-1-Trimethylsilyl-1-Propyne, 98%
LUTETIUMACETATE
(3-Bromo-1-propynyl)trimethylsilane
AS-19351
C6H11BrSi
(3-bromoprop-1-yn-1-yl)(trimethyl)silane
SCHEMBL24235
3-Bromo-1-(trimethylsilyl)-1-propyne
FT-0615117
3-(1-trimethylsilyl)propargyl bromide
3-(Trimethylsilyl)propargyl bromide

MDL Number

MFCD00134460

Customs Code

2931900090

FAQ

What are the physical and chemical properties of (3-Bromo-1-propyn-1-yl)(trimethyl)silane (CAS: 38002-45-8)?

(3-Bromo-1-propyn-1-yl)(trimethyl)silane is a colorless or light yellow liquid with a molecular weight of approximately 185.48 g/mol. It has a high boiling point and is slightly soluble in water but miscible with organic solvents. The compound is known for its reactivity, particularly towards nucleophiles and electrophiles, making it useful in organic synthesis. It can form stable complexes with various metal ions and exhibits significant spectroscopic reactivity.

How is (3-Bromo-1-propyn-1-yl)(trimethyl)silane (CAS: 38002-45-8) typically synthesized?

(3-Bromo-1-propyn-1-yl)(trimethyl)silane is often synthesized using a Grignard reaction starting with 1-bromopropan-1-yl trimethylsilane and 1-propyn-1-ylium trimethylsilane. Commonly, the reaction is carried out in anhydrous ether with magnesium, producing the desired product with good yield. The reaction conditions include the use of a catalytic amount of titanium tetrachloride to improve selectivity and yield.

What industries use (3-Bromo-1-propyn-1-yl)(trimethyl)silane (CAS: 38002-45-8)?

(3-Bromo-1-propyn-1-yl)(trimethyl)silane is primarily used in the pharmaceutical industry for the synthesis of various organic compounds. It also finds applications in polymer chemistry, where it can be used as a silicon source for functionalizing polymers. Additionally, it is utilized in the production of sensors and semiconductors, particularly in the modification of surfaces for improved electronic properties.

What precautions should be taken when handling (3-Bromo-1-propyn-1-yl)(trimethyl)silane (CAS: 38002-45-8)?

When handling (3-Bromo-1-propyn-1-yl)(trimethyl)silane, it is essential to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. Ensure good ventilation in the laboratory by using a fume hood. Store the compound in a cool, dry place away from heat sources and incompatible materials. In case of a spill, immediately contain it and clean up using appropriate waste disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.