5-Chloro-2-fluoro-3-methylpyridine

Basic Information

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CAS Number

375368-84-6

Molecular Formula

C6H5ClFN

Molecular Weight

145.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

49-52°C

Boiling Point

189.4℃ at 760 mmHg

Density

1.264

Flash Point

68.3°C

Refractive Index

1.503

SMILES

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CC1=CC(=CN=C1F)Cl

InChI

InChI=1S/C6H5ClFN/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3

InChIKey

JUDDLKSLYAIQDR-UHFFFAOYSA-N

LogP

2.1825200000000002

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

99.1

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

5-Chloro-2-fluoro-3-methylpyridine
Q-101504
JUDDLKSLYAIQDR-UHFFFAOYSA-N
O11399
2-fluoro-5-chloro-3-picoline
5-chloro-2-fluoro-3-picoline, AldrichCPR
AKOS005258309
A6413
MFCD03095094
AB13483
SCHEMBL635255
SY019985
BCP22093
AC-5408
CS-0210304
DTXSID10654058
DS-0578
5-Chloro-2-fluoro-3-methyl-pyridine;5-Chloro-2-fluoro-3-picoline
5-Chloro-2-fluoro-3-picoline
EN300-1067174
FT-0648089
2-fluoro-5-chloro-3-methylpyridine
375368-84-6
2-fluoro-3-methyl-5-chloropyridine
2-Fluoro-3-methyl-5-chloropyridine

MDL Number

MFCD03095094

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-Chloro-2-fluoro-3-methylpyridine (CAS: 375368-84-6)?

5-Chloro-2-fluoro-3-methylpyridine is a crystalline solid with a molecular weight of approximately 171.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly towards nucleophiles. It is often used in organic synthesis and as a precursor in various chemical processes.

How is 5-Chloro-2-fluoro-3-methylpyridine (CAS: 375368-84-6) typically synthesized?

5-Chloro-2-fluoro-3-methylpyridine can be synthesized via a multistep process, starting with the chlorination of 2-fluoro-3-methylpyridine. Common methods include electrophilic aromatic substitution reactions using chlorine gas or chlorinating reagents. The product is isolated and purified using standard techniques such as recrystallization or column chromatography.

What industries use 5-Chloro-2-fluoro-3-methylpyridine (CAS: 375368-84-6)?

5-Chloro-2-fluoro-3-methylpyridine is primarily used in the pharmaceutical industry for the synthesis of various medicinals. It is also used in the manufacturing of organic semiconductors, where its electronic properties make it suitable for solar cell applications. Additionally, it has potential applications in the polymer industry for developing novel materials.

What precautions should be taken when handling 5-Chloro-2-fluoro-3-methylpyridine (CAS: 375368-84-6)?

When handling 5-Chloro-2-fluoro-3-methylpyridine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.