Amikacin | CAS No. 37517-28-5

Amikacin

Basic Information

View in Editor

CAS Number

37517-28-5

Molecular Formula

C22H43N5O13

Molecular Weight

585.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

203℃

Boiling Point

642.23°C (rough estimate)

Water Solubility

Soluble in water (partly).

Flash Point

547.6 °C

Solubility

H2O: 50 mg/mL, clear, colorless

Refractive Index

1.7500 (estimate)

Specific Rotation

D23 +99° (c = 1.0 in water)

SMILES

View in Editor

C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N

InChI

InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1

InChIKey

LKCWBDHBTVXHDL-RMDFUYIESA-N

LogP

-8.424200000000015

Topological Polar Surface Area

331.94 Å²

Hydrogen Bond Donor/Acceptor

17 / 18

Complexity

819

Safety Information

View Safety Information

Toxicity

LD50 in mice of solns pH 6.6, pH 7.4 (mg/kg): 340, 560 i.v. (Kawaguchi)

Synonyms & References

English

DTXCID002586
Lukadin
Amikavet
Amikacina (INN-Spanish)
NCGC00093350-05
(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide
O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-6))-N(sup 3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine
AMIKACIN (EP MONOGRAPH)
AMIKACIN [MI]
NSC-177001
D06AX12
TD1 - Therapeutic Drug mixture
Amikacina
amikacin
D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4))-N(SUP 1)-(4-AMINO-2-HYDROXY-1-OXOBUTYL)-2-DEOXY-, (S)-
AS-76985
37517-28-5
1-N-(L(-)-gamma-Amino-alpha-hydroxybutyryl)kanamycin A
MFCD11045969
W-106531
AMIKACIN [EP MONOGRAPH]
N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A
HY-B0509A
Amikacina [INN-Spanish]
AKN
Amikacinum
(S)-4-amino-N-((1R,2S,3S,4R,5S)-5-amino-2-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4-(((2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide
CHEMBL177
UNII-84319SGC3C
AMIKACIN [JAN]
Arikace

MDL Number

MFCD00883675

FAQ

What regulatory guidelines apply to Amikacin (CAS: 37517-28-5)?

Amikacin (CAS: 37517-28-5) is subject to various regulatory guidelines including the Globally Harmonized System of Classification and Labeling of Chemicals (GHS), REACH regulations in the European Union, and FDA/EPA requirements for pharmaceuticals and environmental safety. Compliance with these guidelines ensures safe handling, transportation, and disposal.

Are there alternatives to Amikacin (CAS: 37517-28-5) in synthesis?

Alternatives to Amikacin (CAS: 37517-28-5) in synthesis include other aminoglycosides like gentamicin or tobramycin, as well as other antibiotics like beta-lactams. These alternatives can be chosen based on the specific requirements of the synthesis process, such as activity against certain pathogens or ease of synthesis.

What is the market or research trend for Amikacin (CAS: 37517-28-5)?

The market for Amikacin (CAS: 37517-28-5) is stable, with ongoing research focusing on its efficacy against multidrug-resistant bacteria. There is also interest in developing new formulations and combination therapies to enhance its therapeutic profile. Market trends indicate a need for effective antibiotics to combat antibiotic resistance.

How should waste containing Amikacin (CAS: 37517-28-5) be handled?

Waste containing Amikacin (CAS: 37517-28-5) should be collected in appropriate containers, labeled, and disposed of according to local and national regulations. Incineration or professional waste disposal services are recommended to ensure complete destruction and minimize environmental impact. Proper environmental protection measures, such as containment and spill cleanup, should also be followed.