1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone

Basic Information

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CAS Number

37148-47-3

Molecular Formula

C8H6BrCl2NO

Molecular Weight

282.95 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

140-142 ºC

Boiling Point

396.4 °C at 760 mmHg

Flash Point

193.6 °C

Refractive Index

1.643

SMILES

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C1=C(C=C(C(=C1Cl)N)Cl)C(=O)CBr

InChI

InChI=1S/C8H6BrCl2NO/c9-3-7(13)4-1-5(10)8(12)6(11)2-4/h1-2H,3,12H2

InChIKey

ATKJJUFAWYSFID-UHFFFAOYSA-N

LogP

3.153200000000001

Topological Polar Surface Area

43.09 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

191

Synonyms & References

English

37148-47-3
1-(4-amino-3,5-dichlorophenyl)-2-bromoethanone
UNII-9JW68Z2WML
1-(4-AMINO-3,5-DICHLORO-PHENYL)-2-BROMO-ETHANONE
A18701
9JW68Z2WML
(4-Amino-3,5-dichloro-phenyl)-2-bromo-ethanone
s10223
FT-0660508
ATKJJUFAWYSFID-UHFFFAOYSA-N
4-Amino-3,5-dichlorophenacylbromide
4-Amino-3,5-Dichloro-A-Bromo- Acetophenone
4-amino-3,5-dichlorophenacyl bromide
DTXSID10190628
CLENBUTEROL HYDROCHLORIDE IMPURITY E [EP IMPURITY]
(4-amino-3,5dichloro-phenyl)-2-bromo-ethanone
4-AMINO-.ALPHA.-BROMO-3,5-DICHLOROACETOPHENONE
SCHEMBL2876065
EINECS 253-367-6
4'-amino-2-bromo-3',5'-dichloroacetophenone
2-Bromo-4'-Amino-3',5'-Dichloroacetophenone
Ethanone, 1-(4-amino-3,5-dichlorophenyl)-2-bromo-
NS00030162
4'-amino-2-bromo-3', 5'-dichloroacetophenone
AKOS015919493
4-AMINO-.OMEGA.-BROMO-3,5-DICHLOROACETOPHENONE
1-[4-Amino-3,5-dichlorophenyl]-2-bromoethanone
1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-one
1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone
1-(4-Amino-3,5-dichloro-phenyl)-2-bromo-ethanone
1-(4-AMINO-3,5-DICHLORO-PHENYL)-2-BROMO-ETHANONE,YELLOW SOLID

MDL Number

MFCD09743795

Customs Code

2921199090

FAQ

What are the physical and chemical properties of 1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3)?

1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3) is a crystalline compound with a molecular weight of approximately 317.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and ethanol. Chemically, it is highly reactive, particularly towards nucleophiles due to its amino and bromine functionalities.

How is 1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3) typically synthesized?

1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3) is typically synthesized via the reaction of 4-chloro-3,5-dichlorobenzenamine with bromoacetaldehyde dimethyl acetal. The process involves a condensation reaction followed by acetylation. Commonly used catalysts include phosphorus oxychloride, and the yield is around 70-80%. High selectivity towards the desired product can be achieved with optimized reaction conditions.

What industries use 1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3)?

1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3) is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It also finds applications in the polymer industry, where it can be used as a monomer or in the development of sensors and semiconductors due to its specific functional groups.

What precautions should be taken when handling 1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3)?

Handling 1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3) requires careful attention due to its reactivity and toxicity. Wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Use a fume hood during handling and storage. In case of a spill, use absorbent materials and dispose of according to local regulations. Refer to the safety data sheet (SDS) for detailed handling and emergency procedures.