1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone(CAS: 37148-47-3)

1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3) is a crystalline compound with a molecular weight of approximately 317.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and ethanol. Chemically, it is highly reactive, particularly towards nucleophiles due to its amino and bromine functionalities.

1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3) is typically synthesized via the reaction of 4-chloro-3,5-dichlorobenzenamine with bromoacetaldehyde dimethyl acetal. The process involves a condensation reaction followed by acetylation. Commonly used catalysts include phosphorus oxychloride, and the yield is around 70-80%. High selectivity towards the desired product can be achieved with optimized reaction conditions.

1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3) is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It also finds applications in the polymer industry, where it can be used as a monomer or in the development of sensors and semiconductors due to its specific functional groups.

Handling 1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone (CAS: 37148-47-3) requires careful attention due to its reactivity and toxicity. Wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Use a fume hood during handling and storage. In case of a spill, use absorbent materials and dispose of according to local regulations. Refer to the safety data sheet (SDS) for detailed handling and emergency procedures.