6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone

Basic Information

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CAS Number

36725-28-7

Molecular Formula

C11H13N3O

Molecular Weight

203.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

194.0 to 198.0 °C

Density

1.3

Refractive Index

1.652

SMILES

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CC1CC(=O)NN=C1C2=CC=C(C=C2)N

InChI

InChI=1S/C11H13N3O/c1-7-6-10(15)13-14-11(7)8-2-4-9(12)5-3-8/h2-5,7H,6,12H2,1H3,(H,13,15)

InChIKey

GDMRFHZLKNYRRO-UHFFFAOYSA-N

LogP

1.1289

Topological Polar Surface Area

67.48 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

280

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AMY24999
6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)pyridazinone
J-518018
ICI-109081
6-(4-aminophenyl)-5-methyl-4,5-dihydro -3(2H)-pyridazinone
GDMRFHZLKNYRRO-UHFFFAOYSA-N
A800375
SY023998
(6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2h)-pyridazinone)
6-(4-aminophenyl)-4,5-dihydro-5-methylpyridazinone
(-)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone
Levosimendan Impurity 5
GS-3262
6-(4-aminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one
6-(4-amino-phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone
6-(4-Aminophenyl)-5-methyl-4 pound not5-dihydropyridazin-3(2H)-one
4,5-dihydro-6-(4-aminophenyl)-5-methyl-3(2H)-pyridazinone
CS-W022429
Levosimendan dazinones intermediates
6-(4-Aminophenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one
SCHEMBL934905
Ici 109,081
6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
NIOSH/UR6330000
6-(4-aminophenyl)-4,5-dihydro-5-methylpyridazin-3(2H)one
6-(p-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
DTXSID10957950
FT-0600355
4,5-dihydro-6-(4-aminophenyl)-5-methyl-3(2H) pyridazinone
6-(p-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone
BRD-A21608060-001-01-7

MDL Number

MFCD01692712

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (CAS: 36725-28-7)?

6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (CAS: 36725-28-7) is a solid with a white crystalline form. The molecular weight is approximately 240.24 g/mol. It has a solubility of about 5 g/L in water and is slightly soluble in organic solvents. It is moderately reactive with bases and is stable under normal conditions. Suitable for analytical and research purposes.

How is 6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (CAS: 36725-28-7) typically synthesized?

6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (CAS: 36725-28-7) is synthesized via a multi-step process involving condensation reactions, deprotection, and ring formation. Commonly, phenyl isocyanide reacts with 3,4-dimethyl-1H-pyrazol-5(3H)-one in the presence of a suitable catalyst to form the target compound with high yield and selectivity.

What industries use 6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (CAS: 36725-28-7)?

6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (CAS: 36725-28-7) is used in pharmaceuticals for its biological activity, particularly in the development of potential antifungal and antiparasitic agents. It also finds use in the synthesis of other organic compounds and in research for its specific chemical properties.

What precautions should be taken when handling 6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (CAS: 36725-28-7)?

When handling 6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (CAS: 36725-28-7), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed safety information.