2,4-Difluoroaniline

Basic Information

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CAS Number

367-25-9

Molecular Formula

C6H5F2N

Molecular Weight

129.11 g/mol

EINECS

206-687-5

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

−7.5 °C

Boiling Point

170°C

Density

1.268 g/mL at 25 °C

Water Solubility

1-5 g/100 mL at 20.55 ºC

Solubility

Not miscible or difficult to mix.

Refractive Index

n20/D 1.506(lit.)

SMILES

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C1=CC(=C(C=C1F)F)N

InChI

InChI=1S/C6H5F2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2

InChIKey

CEPCPXLLFXPZGW-UHFFFAOYSA-N

LogP

1.547

pKa

3.26±0.10(Predicted)

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

97.1

Safety Information

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Hazard Statement

H227 Combustible liquid
Flammable liquids

H302 Harmful if swallowed
Acute toxicity, oral

H311 Toxic in contact with skin
Acute toxicity, dermal

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Storage Conditions

Keep in dark place,Inert atmosphere,2-8°C

Stability

Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.

RTECS

BX3680000

Synonyms & References

English

Benzenamine,4-difluoro-
BIDD:GT0098
AM20040294
SCHEMBL11425
FT-0601172
2,4-DIFLUOROANILINE
NS00009496
BRN 2802556
EN300-19930
2,4-difluoro-anilin;Aniline, 2,4-difluoro-;Benzenamine, 2,4-difluoro-
40P93L7KWD
2,4-Difluoro Aniline
2,4-DIFLUOROANILINE [MI]
DIFLUOROANILINE, 2,4-
CAS-367-25-9
NCGC00091684-01
CEPCPXLLFXPZGW-UHFFFAOYSA-
2,4 -difluoroaniline
2,4-difluoro-aniline
EC 206-687-5
Z104476120
2,4-Difluoroaniline, 99%
Tox21_200620
W-106593
2,4-di-fluoroaniline
N-Boc-3-MethylnipecoticAcidEthylEster
A25254
Benzenamine, 2,4-difluoro-
2,4-Difluroaniline
367-25-9
Aniline, 2,4-difluoro-

MDL Number

MFCD00007648

EC Number

206-687-5

Customs Code

2921420090

FAQ

What is 2,4-Difluoroaniline (CAS: 367-25-9)?

2,4-Difluoroaniline (CAS: 367-25-9) is a substituted aromatic amine with the chemical formula C6H6F2N. It is a colorless liquid with a pungent odor, known for its reactivity and use as an intermediate in organic synthesis. The compound exhibits moderate solubility in water and organic solvents, and its physical properties include a melting point of approximately -10°C and a boiling point of 200°C.

What are the main uses of 2,4-Difluoroaniline (CAS: 367-25-9)?

2,4-Difluoroaniline (CAS: 367-25-9) is primarily used in pharmaceuticals as a building block for drug development, including antifungal and antibacterial agents. It also serves in industrial applications such as the production of dyes, pesticides, and specialty chemicals. In research, it is valued for its utility in synthesizing fluorinated aromatic compounds and functionalized materials.

Is 2,4-Difluoroaniline (CAS: 367-25-9) safe?

2,4-Difluoroaniline (CAS: 367-25-9) is classified as a hazardous substance due to its potential toxicity. It may cause skin and eye irritation, and prolonged exposure can lead to respiratory issues. Safety precautions include wearing protective gloves, goggles, and a lab coat, and working in a well-ventilated area. Always follow OSHA and REACH guidelines when handling this compound.

How should 2,4-Difluoroaniline (CAS: 367-25-9) be stored?

2,4-Difluoroaniline (CAS: 367-25-9) should be stored in a tightly sealed container in a cool, dry place, away from light and air. It is stable under these conditions but may degrade if exposed to moisture or high temperatures. Store in a flammable storage cabinet and ensure proper labeling to maintain safety and compliance.