Abemaciclib Impurity 5

Basic Information

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CAS Number

367-24-8

Molecular Formula

C6H5BrFN

Molecular Weight

190.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

40.0 to 42.0 deg-C

Boiling Point

122°C/25mmHg

Refractive Index

1.4710 (estimate)

SMILES

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Nc1ccc(Br)cc1F

InChI

InChI=1S/C6H5BrFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2

InChIKey

GZRMNMGWNKSANY-UHFFFAOYSA-N

LogP

2.1704

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

99.1

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Stability

Stable. Incompatible with acid chlorides, acid anhydrides, strong acids, strong oxidizing agents.

Sensitiveness

对空气敏感

Synonyms & References

English

4-Bromo-2-fluoroaniline
Benzenamine, 4-bromo-2-fluoro-
4-BROMO-2-FLUORO-PHENYLAMINE
2-Fluoro-4-Bromoaniline
Bromofluoroaniline4
2-FLUORO-4-BROMOANILINE 0.99 LIGHT YELLOW TRANSPARENT LIQUID OR SOLID
4-brom-2-fluoranilin
Benzenamine,4-bromo-2-fluoro
fluoro-4-bromoaniline
4-bromo-2-fluoro-aniline
4-bromo-2-fluorophenylamine
4-bromo-2-fluorobenzenamine
4-bromo-2-fluoro aniline
F01397E
zlchem 545
PubChem1525
4-bromo-2fluoroaniline
4-bromo-2 fluoroaniline
4-bromo-6-fluoroaniline
4bromo -2-fluoroaniline
4-Brome-2-fluoroaniline
2-fluoro-4-bromo-aniline
2-fluoro-4 -bromoaniline
2-fluoro-4-bromo a

MDL Number

MFCD00010221

Customs Code

2921499090

FAQ

What is Abemaciclib Impurity 5 (CAS: 367-24-8)?

Abemaciclib Impurity 5, with the CAS number 367-24-8, is a chemical compound that serves as an impurity in the production of abemaciclib, a CDK4/6 inhibitor used in cancer therapy. It is typically identified as a byproduct during the synthesis process and may have specific structural characteristics that distinguish it from the active pharmaceutical ingredient.

What are the main uses of Abemaciclib Impurity 5 (CAS: 367-24-8)?

Abemaciclib Impurity 5 is primarily used in the pharmaceutical industry for quality control and purity testing of abemaciclib. It plays a critical role in ensuring the safety and efficacy of the drug by identifying and quantifying potential impurities during drug development and manufacturing processes.

Is Abemaciclib Impurity 5 (CAS: 367-24-8) safe?

Abemaciclib Impurity 5 is generally considered safe when handled according to standard laboratory practices. However, due to its potential chemical reactivity, appropriate safety measures such as wearing personal protective equipment (PPE) and working in a well-ventilated area are recommended. It should be stored securely to prevent contamination and ensure compliance with safety regulations.

How should Abemaciclib Impurity 5 (CAS: 367-24-8) be stored?

Abemaciclib Impurity 5 should be stored in a cool, dry, and dark place, ideally at 2-8°C, to maintain its stability and prevent degradation. It is recommended to keep it in a sealed container to avoid exposure to moisture and air, ensuring it remains chemically inert and suitable for analytical purposes.